2per: Difference between revisions

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-{{Seed}}
-[[Image:2per.png|left|200px]]
-<!--
+==Crystal Structure of Human Chloride Intracellular Channel protein 2==
-The line below this paragraph, containing "STRUCTURE_2per", creates the "Structure Box" on the page.
+<StructureSection load='2per' size='340' side='right'caption='[[2per]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2per]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PER FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNB:5-MERCAPTO-2-NITRO-BENZOIC+ACID'>MNB</scene></td></tr>
-{{STRUCTURE_2per|  PDB=2per  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2per FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2per OCA], [https://pdbe.org/2per PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2per RCSB], [https://www.ebi.ac.uk/pdbsum/2per PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2per ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Note=Defects in CLIC2 are a cause of a mental retardation with cardiopathy and seizures. Cardiac features include atrial fibrillation, cardiomegaly, and congestive heart failure.
+== Function ==
+[https://www.uniprot.org/uniprot/CLIC2_HUMAN CLIC2_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.<ref>PMID:15147738</ref> <ref>PMID:15916532</ref> <ref>PMID:17945253</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pe/2per_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2per ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Human Chloride Intracellular Channel protein 2===
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-PER is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PER OCA].
+__TOC__
+</StructureSection>
-==Reference==
-The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications., Mi W, Liang YH, Li L, Su XD, Proteins. 2008 Apr;71(1):509-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18186468 18186468]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Liang, Y H.]]
+[[Category: Liang YH]]
-[[Category: Mi, W.]]
+[[Category: Mi W]]
-[[Category: Su, X D.]]
+[[Category: Su XD]]
-[[Category: Clic2]]
-[[Category: Disulfide bond]]
-[[Category: Electron transport]]
-[[Category: Gst fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:46:52 2008''