2h3p: Difference between revisions

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[[Image:2h3p.png|left|200px]]


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==Crystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoA==
The line below this paragraph, containing "STRUCTURE_2h3p", creates the "Structure Box" on the page.
<StructureSection load='2h3p' size='340' side='right'caption='[[2h3p]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2h3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=152:CARNITINE'>152</scene>, <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
{{STRUCTURE_2h3p| PDB=2h3p |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3p OCA], [https://pdbe.org/2h3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3p RCSB], [https://www.ebi.ac.uk/pdbsum/2h3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CACP_MOUSE CACP_MOUSE] Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/2h3p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h3p ConSurf].
<div style="clear:both"></div>


===Crystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoA===
==See Also==
 
*[[Carnitine acetyltransferase|Carnitine acetyltransferase]]
 
__TOC__
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16870616}}
 
==About this Structure==
2H3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3P OCA].
 
==Reference==
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates., Hsiao YS, Jogl G, Tong L, J Biol Chem. 2006 Sep 22;281(38):28480-7. Epub 2006 Jul 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16870616 16870616]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Hsiao YS]]
[[Category: Hsiao, Y S.]]
[[Category: Jogl G]]
[[Category: Jogl, G.]]
[[Category: Tong L]]
[[Category: Tong, L.]]
[[Category: Carnitine acyltransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:28:45 2008''

Latest revision as of 12:30, 14 February 2024

Crystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoACrystal structure of murine carnitine acetyltransferase in complex with carnitine and acetyl-CoA

Structural highlights

2h3p is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CACP_MOUSE Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2h3p, resolution 2.20Å

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