1z8a: Difference between revisions

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[[Image:1z8a.png|left|200px]]


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==Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor==
The line below this paragraph, containing "STRUCTURE_1z8a", creates the "Structure Box" on the page.
<StructureSection load='1z8a' size='340' side='right'caption='[[1z8a]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1z8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z8A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=62P:6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE'>62P</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_1z8a| PDB=1z8a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8a OCA], [https://pdbe.org/1z8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z8a RCSB], [https://www.ebi.ac.uk/pdbsum/1z8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z8a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z8/1z8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z8a ConSurf].
<div style="clear:both"></div>


===Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor===
==See Also==
 
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_16337231}}
 
==About this Structure==
1Z8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8A OCA].
 
==Reference==
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group., Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G, J Mol Biol. 2006 Feb 10;356(1):45-56. Epub 2005 Nov 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16337231 16337231]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Heine, A.]]
[[Category: Heine A]]
[[Category: Klebe, G.]]
[[Category: Klebe G]]
[[Category: Podjarny, A.]]
[[Category: Podjarny A]]
[[Category: Steuber, H.]]
[[Category: Steuber H]]
[[Category: Zentgraf, M.]]
[[Category: Zentgraf M]]
[[Category: Double conformation]]
[[Category: Protein-ligand complex]]
[[Category: Tim-barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:20:51 2008''

Latest revision as of 16:39, 13 March 2024

Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone InhibitorHuman Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor

Structural highlights

1z8a is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALDR_HUMAN Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1z8a, resolution 0.95Å

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