2g69: Difference between revisions

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[[Image:2g69.png|left|200px]]


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==Structure of Unliganded HIV-1 Protease F53L Mutant==
The line below this paragraph, containing "STRUCTURE_2g69", creates the "Structure Box" on the page.
<StructureSection load='2g69' size='340' side='right'caption='[[2g69]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2g69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G69 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g69 OCA], [https://pdbe.org/2g69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g69 RCSB], [https://www.ebi.ac.uk/pdbsum/2g69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g69 ProSAT]</span></td></tr>
{{STRUCTURE_2g69|  PDB=2g69 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/2g69_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g69 ConSurf].
<div style="clear:both"></div>


===Structure of Unliganded HIV-1 Protease F53L Mutant===
==See Also==
 
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
 
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</StructureSection>
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{{ABSTRACT_PUBMED_16569415}}
 
==About this Structure==
2G69 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G69 OCA].
 
==Reference==
Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation., Liu F, Kovalevsky AY, Louis JM, Boross PI, Wang YF, Harrison RW, Weber IT, J Mol Biol. 2006 May 19;358(5):1191-9. Epub 2006 Mar 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16569415 16569415]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Kovalevsky, A Y.]]
[[Category: Kovalevsky AY]]
[[Category: Liu, F.]]
[[Category: Liu F]]
[[Category: Aspartic protease]]
[[Category: Catalysis]]
[[Category: Flap mutant]]
[[Category: Non-active site mutant]]
[[Category: Unliganded]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:06:19 2008''

Latest revision as of 12:26, 14 February 2024

Structure of Unliganded HIV-1 Protease F53L MutantStructure of Unliganded HIV-1 Protease F53L Mutant

Structural highlights

2g69 is a 1 chain structure with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.35Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q7SSI0_9HIV1

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g69, resolution 1.35Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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