1py9: Difference between revisions

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-{{Seed}}
-[[Image:1py9.png|left|200px]]
-<!--
+==The crystal structure of an autoantigen in multiple sclerosis==
-The line below this paragraph, containing "STRUCTURE_1py9", creates the "Structure Box" on the page.
+<StructureSection load='1py9' size='340' side='right'caption='[[1py9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1py9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PY9 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1py9|  PDB=1py9  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1py9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1py9 OCA], [https://pdbe.org/1py9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1py9 RCSB], [https://www.ebi.ac.uk/pdbsum/1py9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1py9 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE] Note=Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.
+== Function ==
+[https://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE] Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.<ref>PMID:12960396</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/1py9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1py9 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. To gain new insights into the physiological and immunopathological role of MOG, we determined the 1.8-A crystal structure of the MOG extracellular domain (MOGED). MOGED adopts a classical Ig (Ig variable domain) fold that was observed to form an antiparallel head-to-tail dimer. A dimeric form of native MOG was observed, and MOGED was also shown to dimerize in solution, consistent with the view of MOG acting as a homophilic adhesion receptor. The MOG35-55 peptide, a major encephalitogenic determinant recognized by both T cells and demyelinating autoantibodies, is partly occluded within the dimer interface. The structure of this key autoantigen suggests a relationship between the dimeric form of MOG within the myelin sheath and a breakdown of immunological tolerance to MOG that is observed in multiple sclerosis.
-===The crystal structure of an autoantigen in multiple sclerosis===
+The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis.,Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5. PMID:12960396<ref>PMID:12960396</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12960396}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1py9" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12960396 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12960396}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-PY9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY9 OCA].
-==Reference==
-The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis., Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J, Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12960396 12960396]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Beddoe T]]
-[[Category: Beddoe, T.]]
+[[Category: Bernard CC]]
-[[Category: Bernard, C C.]]
+[[Category: Clements CS]]
-[[Category: Clements, C S.]]
+[[Category: Johns TG]]
-[[Category: Johns, T G.]]
+[[Category: Perugini MA]]
-[[Category: Perugini, M A.]]
+[[Category: Reid HH]]
-[[Category: Reid, H H.]]
+[[Category: Rossjohn J]]
-[[Category: Rossjohn, J.]]
+[[Category: Tynan FE]]
-[[Category: Tynan, F E.]]
-[[Category: Anti-parallel dimer]]
-[[Category: Immunoglobulin]]
-[[Category: Multiple sclerosis]]
-[[Category: Myelin sheath]]
-[[Category: Receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:51:42 2008''