2g95: Difference between revisions

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-{{Seed}}
-[[Image:2g95.png|left|200px]]
-<!--
+==Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase==
-The line below this paragraph, containing "STRUCTURE_2g95", creates the "Structure Box" on the page.
+<StructureSection load='2g95' size='340' side='right'caption='[[2g95]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2g95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G95 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g95 OCA], [https://pdbe.org/2g95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g95 RCSB], [https://www.ebi.ac.uk/pdbsum/2g95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g95 ProSAT]</span></td></tr>
-{{STRUCTURE_2g95|  PDB=2g95  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g9/2g95_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g95 ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Visfatin/Pre-B Cell Colony Enhancing Factor 1/Nicotinamide Phosphoribosyltransferase===
+==See Also==
+*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16901503}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16901503 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_16901503}}
-==About this Structure==
-G95 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G95 OCA].
-==Reference==
-Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866., Kim MK, Lee JH, Kim H, Park SJ, Kim SH, Kang GB, Lee YS, Kim JB, Kim KK, Suh SW, Eom SH, J Mol Biol. 2006 Sep 8;362(1):66-77. Epub 2006 Aug 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16901503 16901503]
-[[Category: Nicotinamide phosphoribosyltransferase]]
 [[Category: Rattus norvegicus]]
-[[Category: Single protein]]
+[[Category: Eom SH]]
-[[Category: Eom, S H.]]
+[[Category: Kim M-K]]
-[[Category: Kim, M K.]]
-[[Category: Namprtase]]
-[[Category: Pbef]]
-[[Category: Rattus norvegicus]]
-[[Category: Visfatin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:27 2008''