1w0y: Difference between revisions

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-{{Seed}}
-[[Image:1w0y.png|left|200px]]
-<!--
+==tf7a_3771 complex==
-The line below this paragraph, containing "STRUCTURE_1w0y", creates the "Structure Box" on the page.
+<StructureSection load='1w0y' size='340' side='right'caption='[[1w0y]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1w0y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0Y FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=771:4-(4-BENZYLOXY-2-METHANESULFONYLAMINO-5-METHOXY-BENZYLAMINO)-BENZAMIDINE'>771</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-{{STRUCTURE_1w0y|  PDB=1w0y  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0y OCA], [https://pdbe.org/1w0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0y RCSB], [https://www.ebi.ac.uk/pdbsum/1w0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0y ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/1w0y_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w0y ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Proof of concept experiments have shown that tissue factor/factor VIIa inhibitors have antithrombotic activity without enhancing bleeding propensity. Starting from lead compounds generated by a biased combinatorial approach, phenylglycine amide tissue factor/factor VIIa inhibitors with low nanomolar affinity and good selectivity against other serine proteases of the coagulation cascade were designed, using the guidance of X-ray structural analysis and molecular modelling.
-===TF7A_3771 COMPLEX===
+Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors.,Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864<ref>PMID:15664864</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1w0y" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_15664864}}, adds the Publication Abstract to the page
+*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 15664864 is the PubMed ID number.
+*[[Tissue factor|Tissue factor]]
--->
+== References ==
-{{ABSTRACT_PUBMED_15664864}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-W0Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0Y OCA].
-==Reference==
-Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15664864 15664864]
-[[Category: Coagulation factor VIIa]]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Ackermann, J.]]
+[[Category: Ackermann J]]
-[[Category: Arcy, A D.]]
+[[Category: Banner DW]]
-[[Category: Banner, D W.]]
+[[Category: D'Arcy A]]
-[[Category: Groebke-Zbinden, K.]]
+[[Category: Groebke-Zbinden K]]
-[[Category: Ji, Y H.]]
+[[Category: Ji Y-H]]
-[[Category: Kirchhofer, D.]]
+[[Category: Kirchhofer D]]
-[[Category: Tschopp, T B.]]
+[[Category: Tschopp TB]]
-[[Category: Wallbaum, S.]]
+[[Category: Wallbaum S]]
-[[Category: Weber, L.]]
+[[Category: Weber L]]
-[[Category: Blood coagulation]]
-[[Category: Calcium-binding]]
-[[Category: Co-factor]]
-[[Category: Coagulation]]
-[[Category: Enzyme complex]]
-[[Category: Gamma-carboxyglutamic acid]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Plasma]]
-[[Category: Serine protease]]
-[[Category: Vitamin k]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:10:12 2008''