2dh4: Difference between revisions

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[[Image:2dh4.png|left|200px]]


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==Geranylgeranyl pyrophosphate synthase==
The line below this paragraph, containing "STRUCTURE_2dh4", creates the "Structure Box" on the page.
<StructureSection load='2dh4' size='340' side='right'caption='[[2dh4]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2dh4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DH4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2dh4| PDB=2dh4 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dh4 OCA], [https://pdbe.org/2dh4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dh4 RCSB], [https://www.ebi.ac.uk/pdbsum/2dh4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dh4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GGPPS_YEAST GGPPS_YEAST] Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.<ref>PMID:7665600</ref> <ref>PMID:15296494</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dh4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dh4 ConSurf].
<div style="clear:both"></div>


===Geranylgeranyl pyrophosphate synthase===
==See Also==
 
*[[Geranylgeranyl pyrophosphate synthase 3D structures|Geranylgeranyl pyrophosphate synthase 3D structures]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16554305}}
 
==About this Structure==
2DH4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DH4 OCA].
 
==Reference==
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination., Chang TH, Guo RT, Ko TP, Wang AH, Liang PH, J Biol Chem. 2006 May 26;281(21):14991-5000. Epub 2006 Mar 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16554305 16554305]
[[Category: Farnesyltranstransferase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Chang T-H]]
[[Category: Chang, T H.]]
[[Category: Guo R-T]]
[[Category: Guo, R T.]]
[[Category: Ko T-P]]
[[Category: Ko, T P.]]
[[Category: Liang P-H]]
[[Category: Liang, P H.]]
[[Category: Wang AH]]
[[Category: Wang, A H.]]
[[Category: Alpha helix]]
[[Category: Prenyl transferase]]
[[Category: Pyrophosphate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:32:20 2008''

Latest revision as of 16:47, 13 March 2024

Geranylgeranyl pyrophosphate synthaseGeranylgeranyl pyrophosphate synthase

Structural highlights

2dh4 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.98Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GGPPS_YEAST Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Jiang Y, Proteau P, Poulter D, Ferro-Novick S. BTS1 encodes a geranylgeranyl diphosphate synthase in Saccharomyces cerevisiae. J Biol Chem. 1995 Sep 15;270(37):21793-9. PMID:7665600
  2. ↑ Shiflett SL, Vaughn MB, Huynh D, Kaplan J, Ward DM. Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Traffic. 2004 Sep;5(9):700-10. PMID:15296494 doi:http://dx.doi.org/10.1111/j.1600-0854.2004.00213.x

2dh4, resolution 1.98Å

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