2av5: Difference between revisions

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[[Image:2av5.png|left|200px]]


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==Crystal structure of Pyrococcus furiosus Pop5, an archaeal Ribonuclease P protein==
The line below this paragraph, containing "STRUCTURE_2av5", creates the "Structure Box" on the page.
<StructureSection load='2av5' size='340' side='right'caption='[[2av5]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2av5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AV5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2av5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2av5 OCA], [https://pdbe.org/2av5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2av5 RCSB], [https://www.ebi.ac.uk/pdbsum/2av5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2av5 ProSAT]</span></td></tr>
{{STRUCTURE_2av5| PDB=2av5 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNP2_PYRFU RNP2_PYRFU] Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.<ref>PMID:17053064</ref> <ref>PMID:21683084</ref> <ref>PMID:22298511</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/av/2av5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2av5 ConSurf].
<div style="clear:both"></div>


===Crystal structure of Pyrococcus furiosus Pop5, an archaeal Ribonuclease P protein===
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16418270}}
 
==About this Structure==
2AV5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AV5 OCA].
 
==Reference==
Structure of Pfu Pop5, an archaeal RNase P protein., Wilson RC, Bohlen CJ, Foster MP, Bell CE, Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):873-8. Epub 2006 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16418270 16418270]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Ribonuclease P]]
[[Category: Bell CE]]
[[Category: Single protein]]
[[Category: Bohlen CJ]]
[[Category: Bell, C E.]]
[[Category: Foster MP]]
[[Category: Bohlen, C J.]]
[[Category: Wilson RC]]
[[Category: Foster, M P.]]
[[Category: Wilson, R C.]]
[[Category: Ribonuclease p]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:31:03 2008''

Latest revision as of 12:14, 14 February 2024

Crystal structure of Pyrococcus furiosus Pop5, an archaeal Ribonuclease P proteinCrystal structure of Pyrococcus furiosus Pop5, an archaeal Ribonuclease P protein

Structural highlights

2av5 is a 5 chain structure with sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.15Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNP2_PYRFU Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Tsai HY, Pulukkunat DK, Woznick WK, Gopalan V. Functional reconstitution and characterization of Pyrococcus furiosus RNase P. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16147-52. Epub 2006 Oct 19. PMID:17053064 doi:http://dx.doi.org/10.1073/pnas.0608000103
  2. ↑ Chen WY, Xu Y, Cho IM, Oruganti SV, Foster MP, Gopalan V. Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P. J Mol Biol. 2011 Aug 12;411(2):368-83. doi: 10.1016/j.jmb.2011.05.012. Epub 2011 , Jun 12. PMID:21683084 doi:http://dx.doi.org/10.1016/j.jmb.2011.05.012
  3. ↑ Chen WY, Singh D, Lai LB, Stiffler MA, Lai HD, Foster MP, Gopalan V. Fidelity of tRNA 5'-maturation: a possible basis for the functional dependence of archaeal and eukaryal RNase P on multiple protein cofactors. Nucleic Acids Res. 2012 May;40(10):4666-80. doi: 10.1093/nar/gks013. Epub 2012, Jan 31. PMID:22298511 doi:http://dx.doi.org/10.1093/nar/gks013

2av5, resolution 3.15Å

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