1w7x: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:1w7x.png|left|200px]]
-<!--
+==Factor7 - 413 complex==
-The line below this paragraph, containing "STRUCTURE_1w7x", creates the "Structure Box" on the page.
+<StructureSection load='1w7x' size='340' side='right'caption='[[1w7x]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1w7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7X FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=413:(S)-[(R)-2-(4-BENZYLOXY-3-METHOXY-PHENYL)-2-(4-CARBAMIMIDOYL-PHENYLAMINO)-ACETYLAMINO]-PHENYL-ACETIC+ACID'>413</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1w7x|  PDB=1w7x  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7x OCA], [https://pdbe.org/1w7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7x RCSB], [https://www.ebi.ac.uk/pdbsum/1w7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7x ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/1w7x_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w7x ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
-===FACTOR7- 413 COMPLEX===
+Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.,Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138<ref>PMID:16213138</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1w7x" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16213138}}, adds the Publication Abstract to the page
+*[[Factor VIIa 3D structures|Factor VIIa 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16213138 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16213138}}
+__TOC__
+</StructureSection>
-==About this Structure==
-W7X is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7X OCA].
-==Reference==
-Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16213138 16213138]
-[[Category: Coagulation factor VIIa]]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Ackermann, J.]]
+[[Category: Ackermann J]]
-[[Category: Alig, L.]]
+[[Category: Alig L]]
-[[Category: Banner, D W.]]
+[[Category: Banner DW]]
-[[Category: Boehm, H J.]]
+[[Category: Boehm H-J]]
-[[Category: Groebke-Zbinden, K.]]
+[[Category: Groebke-Zbinden K]]
-[[Category: Hilpert, K.]]
+[[Category: Hilpert K]]
-[[Category: Kuehne, H.]]
+[[Category: Kuehne H]]
-[[Category: Lave, T.]]
+[[Category: Lave T]]
-[[Category: Obst-Sander, U.]]
+[[Category: Obst-Sander U]]
-[[Category: Riederer, M.]]
+[[Category: Riederer MA]]
-[[Category: Stahl, M.]]
+[[Category: Stahl M]]
-[[Category: Tschopp, T B.]]
+[[Category: Tschopp TB]]
-[[Category: Weber, L.]]
+[[Category: Weber L]]
-[[Category: Wessel, H P.]]
+[[Category: Wessel HP]]
-[[Category: Coagulation]]
-[[Category: Enzyme complex]]
-[[Category: Serine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:08:10 2008''