1qj5: Difference between revisions

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{{Seed}}
[[Image:1qj5.png|left|200px]]


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==Crystal structure of 7,8-diaminopelargonic acid synthase==
The line below this paragraph, containing "STRUCTURE_1qj5", creates the "Structure Box" on the page.
<StructureSection load='1qj5' size='340' side='right'caption='[[1qj5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1qj5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
{{STRUCTURE_1qj5| PDB=1qj5 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qj5 OCA], [https://pdbe.org/1qj5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qj5 RCSB], [https://www.ebi.ac.uk/pdbsum/1qj5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qj5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIOA_ECOLI BIOA_ECOLI] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.<ref>PMID:1092681</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/1qj5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qj5 ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF 7,8-DIAMINOPELARGONIC ACID SYNTHASE===
==See Also==
 
*[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]]
 
== References ==
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_10452893}}
[[Category: Gibson KJ]]
 
[[Category: Kack H]]
==About this Structure==
[[Category: Lindqvist Y]]
1QJ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJ5 OCA].
[[Category: Sandmark J]]
 
[[Category: Schneider G]]
==Reference==
Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes., Kack H, Sandmark J, Gibson K, Schneider G, Lindqvist Y, J Mol Biol. 1999 Aug 27;291(4):857-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10452893 10452893]
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Gibson, K J.]]
[[Category: Kack, H.]]
[[Category: Lindqvist, Y.]]
[[Category: Sandmark, J.]]
[[Category: Schneider, G.]]
[[Category: Aminotransferase]]
[[Category: Biotin biosynthesis]]
[[Category: Pyridoxal-5'-phosphate]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:32:41 2008''

Latest revision as of 09:03, 17 April 2024

Crystal structure of 7,8-diaminopelargonic acid synthaseCrystal structure of 7,8-diaminopelargonic acid synthase

Structural highlights

1qj5 is a 2 chain structure with sequence from Escherichia coli BL21(DE3). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BIOA_ECOLI Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Stoner GL, Eisenberg MA. Purification and properties of 7, 8-diaminopelargonic acid aminotransferase. J Biol Chem. 1975 Jun 10;250(11):4029-36. PMID:1092681

1qj5, resolution 1.80Å

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