2jcp: Difference between revisions

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[[Image:2jcp.png|left|200px]]


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==The hyaluronan binding domain of murine CD44==
The line below this paragraph, containing "STRUCTURE_2jcp", creates the "Structure Box" on the page.
<StructureSection load='2jcp' size='340' side='right'caption='[[2jcp]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jcp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JCP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jcp OCA], [https://pdbe.org/2jcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jcp RCSB], [https://www.ebi.ac.uk/pdbsum/2jcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jcp ProSAT]</span></td></tr>
{{STRUCTURE_2jcp| PDB=2jcp |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jcp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jcp ConSurf].
<div style="clear:both"></div>


===THE HYALURONAN BINDING DOMAIN OF MURINE CD44===
==See Also==
 
*[[CD44|CD44]]
 
__TOC__
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_17293874}}
 
==About this Structure==
2JCP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JCP OCA].
 
==Reference==
Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction., Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG, Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17293874 17293874]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Banerji S]]
[[Category: Banerji, S.]]
[[Category: Campbell ID]]
[[Category: Campbell, I D.]]
[[Category: Day AJ]]
[[Category: Day, A J.]]
[[Category: Jackson DG]]
[[Category: Jackson, D G.]]
[[Category: Mahoney DJ]]
[[Category: Mahoney, D J.]]
[[Category: Noble MEM]]
[[Category: Noble, M E.M.]]
[[Category: Wright AJ]]
[[Category: Wright, A J.]]
[[Category: Alternative splicing]]
[[Category: Antigen]]
[[Category: Blood group antigen]]
[[Category: C-type lectin]]
[[Category: Cell adhesion]]
[[Category: Extracellular matrix]]
[[Category: Glycoprotein]]
[[Category: Hyauronan]]
[[Category: Lectin]]
[[Category: Link-domain]]
[[Category: Membrane]]
[[Category: Phosphorylation]]
[[Category: Polymorphism]]
[[Category: Proteoglycan]]
[[Category: Pyrrolidone carboxylic acid]]
[[Category: Receptor]]
[[Category: Sugar- binding]]
[[Category: Sugar-binding protein]]
[[Category: Sulfation]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:58:15 2008''

Latest revision as of 10:46, 7 February 2024

The hyaluronan binding domain of murine CD44The hyaluronan binding domain of murine CD44

Structural highlights

2jcp is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD44_MOUSE Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2jcp, resolution 1.30Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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