1nd4: Difference between revisions

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-{{Seed}}
-[[Image:1nd4.png|left|200px]]
-<!--
+==Crystal structure of aminoglycoside-3'-phosphotransferase-IIa==
-The line below this paragraph, containing "STRUCTURE_1nd4", creates the "Structure Box" on the page.
+<StructureSection load='1nd4' size='340' side='right'caption='[[1nd4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1nd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ND4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=KAN:KANAMYCIN+A'>KAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-{{STRUCTURE_1nd4|  PDB=1nd4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd4 OCA], [https://pdbe.org/1nd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nd4 RCSB], [https://www.ebi.ac.uk/pdbsum/1nd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KKA2_KLEPN KKA2_KLEPN] Resistance to kanamycin, neomycin, paromomycin, ribostamycin, butirosin and gentamicin B.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nd/1nd4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nd4 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of aminoglycoside-3'-phosphotransferase-IIa===
+==See Also==
+*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_12628253}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 12628253 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_12628253}}
-==About this Structure==
-ND4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND4 OCA].
-==Reference==
-The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance., Nurizzo D, Shewry SC, Perlin MH, Brown SA, Dholakia JN, Fuchs RL, Deva T, Baker EN, Smith CA, J Mol Biol. 2003 Mar 21;327(2):491-506. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12628253 12628253]
-[[Category: Kanamycin kinase]]
 [[Category: Klebsiella pneumoniae]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Baker, E N.]]
+[[Category: Baker EN]]
-[[Category: Nurizzo, D.]]
+[[Category: Nurizzo D]]
-[[Category: Shewry, S C.]]
+[[Category: Shewry SC]]
-[[Category: Smith, C A.]]
+[[Category: Smith CA]]
-[[Category: Atpase]]
-[[Category: Kanamycin]]
-[[Category: Phosphotransferase]]
-[[Category: Protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:21:19 2008''