5ldh: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:5ldh.gif|left|200px]]<br /><applet load="5ldh" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="5ldh, resolution 2.7&Aring;" />
-'''STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION'''<br />
-==About this Structure==
+==STRUCTURE OF THE ACTIVE TERNARY COMPLEX OF PIG HEART LACTATE DEHYDROGENASE WITH S-LAC-NAD AT 2.7 ANGSTROMS RESOLUTION==
-LDH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with ACE, LNC and CIT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=5LDH OCA].
+<StructureSection load='5ldh' size='340' side='right'caption='[[5ldh]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ldh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LDH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LNC:(3S)-5-(3-CARBOXY-3-HYDROXYPROPYL)+NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>LNC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ldh OCA], [https://pdbe.org/5ldh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ldh RCSB], [https://www.ebi.ac.uk/pdbsum/5ldh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ldh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LDHB_PIG LDHB_PIG]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/5ldh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5ldh ConSurf].
+<div style="clear:both"></div>
-==Reference==
+==See Also==
-Structure of the active ternary complex of pig heart lactate dehydrogenase with S-lac-NAD at 2.7 A resolution., Grau UM, Trommer WE, Rossmann MG, J Mol Biol. 1981 Sep 15;151(2):289-307. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7338899 7338899]
+*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
-[[Category: L-lactate dehydrogenase]]
+__TOC__
-[[Category: Single protein]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Grau, U.M.]]
+[[Category: Grau UM]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann MG]]
-[[Category: ACE]]
-[[Category: CIT]]
-[[Category: LNC]]
-[[Category: choh donor]]
-[[Category: nad acceptr]]
-[[Category: oxidoreductase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:34:41 2007''