1s1f: Difference between revisions

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-{{Seed}}
-[[Image:1s1f.png|left|200px]]
-<!--
+==Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways==
-The line below this paragraph, containing "STRUCTURE_1s1f", creates the "Structure Box" on the page.
+<StructureSection load='1s1f' size='340' side='right'caption='[[1s1f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1s1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=PIM:4-PHENYL-1H-IMIDAZOLE'>PIM</scene></td></tr>
-{{STRUCTURE_1s1f|  PDB=1s1f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1f OCA], [https://pdbe.org/1s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1f RCSB], [https://www.ebi.ac.uk/pdbsum/1s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1f ProSAT]</span></td></tr>
+</table>
-===Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways===
+== Function ==
+[https://www.uniprot.org/uniprot/C1582_STRCO C1582_STRCO] Catalyze oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin).<ref>PMID:15659395</ref> <ref>PMID:16239228</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_15659395}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 15659395 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1f_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_15659395}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-S1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1F OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1f ConSurf].
+<div style="clear:both"></div>
-==Reference==
+== References ==
-Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2., Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR, J Biol Chem. 2005 Mar 25;280(12):11599-607. Epub 2005 Jan 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15659395 15659395]
+<references/>
-[[Category: Bacteria]]
+__TOC__
-[[Category: Single protein]]
+</StructureSection>
-[[Category: Lamb, D C.]]
+[[Category: Large Structures]]
-[[Category: Lei, L.]]
+[[Category: Lamb DC]]
-[[Category: Podust, L M.]]
+[[Category: Lei L]]
-[[Category: Sundaramoorthy, M.]]
+[[Category: Podust LM]]
-[[Category: Waterman, M R.]]
+[[Category: Sundaramoorthy M]]
-[[Category: Zhao, B.]]
+[[Category: Waterman MR]]
-[[Category: Antibiotic biosynthesis]]
+[[Category: Zhao B]]
-[[Category: Cyp158a2]]
-[[Category: Cytochrome p450 oxidoreductase]]
-[[Category: Streptomyce]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:26:58 2008''