1r2m: Difference between revisions

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-{{Seed}}
-[[Image:1r2m.png|left|200px]]
-<!--
+==Atomic resolution structure of the HFBII hydrophobin: a self-assembling amphiphile==
-The line below this paragraph, containing "STRUCTURE_1r2m", creates the "Structure Box" on the page.
+<StructureSection load='1r2m' size='340' side='right'caption='[[1r2m]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1r2m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2M FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-{{STRUCTURE_1r2m|  PDB=1r2m  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2m OCA], [https://pdbe.org/1r2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2m RCSB], [https://www.ebi.ac.uk/pdbsum/1r2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2m ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HYP2_HYPJE HYP2_HYPJE] Responsible for spore hydrophobicity and protection.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/1r2m_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r2m ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Hydrophobins are proteins specific to filamentous fungi. Hydrophobins have several important roles in fungal physiology, for example, adhesion, formation of protective surface coatings, and the reduction of the surface tension of water, which allows growth of aerial structures. Hydrophobins show remarkable biophysical properties, for example, they are the most powerful surface-active proteins known. To this point the molecular basis of the function of this group of proteins has been largely unknown. We have now determined the crystal structure of the hydrophobin HFBII from Trichoderma reesei at 1.0 A resolution. HFBII has a novel, compact single domain structure containing one alpha-helix and four antiparallel beta-strands that completely envelop two disulfide bridges. The protein surface is mainly hydrophilic, but two beta-hairpin loops contain several conserved aliphatic side chains that form a flat hydrophobic patch that makes the molecule amphiphilic. The amphiphilicity of the HFBII molecule is expected to be a source for surface activity, and we suggest that the behavior of this surfactant is greatly enhanced by the self-assembly that is favored by the combination of size and rigidity. This mechanism of function is supported by atomic force micrographs that show highly ordered arrays of HFBII at the air water interface. The data presented show that much of the current views on structure function relations in hydrophobins must be re-evaluated.
-===Atomic resolution structure of the HFBII hydrophobin: a self-assembling amphiphile===
+Atomic resolution structure of the HFBII hydrophobin, a self-assembling amphiphile.,Hakanpaa J, Paananen A, Askolin S, Nakari-Setala T, Parkkinen T, Penttila M, Linder MB, Rouvinen J J Biol Chem. 2004 Jan 2;279(1):534-9. Epub 2003 Oct 10. PMID:14555650<ref>PMID:14555650</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_14555650}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1r2m" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 14555650 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_14555650}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-R2M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2M OCA].
+[[Category: Trichoderma reesei]]
+[[Category: Askolin S]]
-==Reference==
+[[Category: Hakanpaa J]]
-Atomic resolution structure of the HFBII hydrophobin, a self-assembling amphiphile., Hakanpaa J, Paananen A, Askolin S, Nakari-Setala T, Parkkinen T, Penttila M, Linder MB, Rouvinen J, J Biol Chem. 2004 Jan 2;279(1):534-9. Epub 2003 Oct 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14555650 14555650]
+[[Category: Linder MB]]
-[[Category: Hypocrea jecorina]]
+[[Category: Nakari-Setala T]]
-[[Category: Single protein]]
+[[Category: Paananen A]]
-[[Category: Askolin, S.]]
+[[Category: Parkkinen T]]
-[[Category: Hakanpaa, J.]]
+[[Category: Penttila M]]
-[[Category: Linder, M B.]]
+[[Category: Rouvinen J]]
-[[Category: Nakari-Setala, T.]]
-[[Category: Paananen, A.]]
-[[Category: Parkkinen, T.]]
-[[Category: Penttila, M.]]
-[[Category: Rouvinen, J.]]
-[[Category: Amphiphile]]
-[[Category: Fungi]]
-[[Category: Protein surfactant]]
-[[Category: Self-assembly]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:07:53 2008''