1owj: Difference between revisions

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-{{Seed}}
-[[Image:1owj.png|left|200px]]
-<!--
+==Substituted 2-Naphthamidine Inhibitors of Urokinase==
-The line below this paragraph, containing "STRUCTURE_1owj", creates the "Structure Box" on the page.
+<StructureSection load='1owj' size='340' side='right'caption='[[1owj]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1owj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OWJ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=155:6-[(Z)-AMINO(IMINO)METHYL]-N-(1-ISOPROPYL-3,4-DIHYDROISOQUINOLIN-7-YL)-2-NAPHTHAMIDE'>155</scene></td></tr>
-{{STRUCTURE_1owj|  PDB=1owj  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1owj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1owj OCA], [https://pdbe.org/1owj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1owj RCSB], [https://www.ebi.ac.uk/pdbsum/1owj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1owj ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ow/1owj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1owj ConSurf].
+<div style="clear:both"></div>
-===Substituted 2-Naphthamidine Inhibitors of Urokinase===
+==See Also==
+*[[Urokinase 3D Structures|Urokinase 3D Structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_14711304}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 14711304 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_14711304}}
-==Disease==
-Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
-==About this Structure==
-OWJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OWJ OCA].
-==Reference==
-Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution., Wendt MD, Rockway TW, Geyer A, McClellan W, Weitzberg M, Zhao X, Mantei R, Nienaber VL, Stewart K, Klinghofer V, Giranda VL, J Med Chem. 2004 Jan 15;47(2):303-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14711304 14711304]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: U-plasminogen activator]]
+[[Category: Geyer A]]
-[[Category: Geyer, A.]]
+[[Category: Giranda VL]]
-[[Category: Giranda, V L.]]
+[[Category: Klinghofer V]]
-[[Category: Klinghofer, V.]]
+[[Category: Mantei R]]
-[[Category: Mantei, R.]]
+[[Category: McClellan W]]
-[[Category: McClellan, W.]]
+[[Category: Nienaber VL]]
-[[Category: Nienaber, V L.]]
+[[Category: Rockway TW]]
-[[Category: Rockway, T W.]]
+[[Category: Stewart K]]
-[[Category: Stewart, K.]]
+[[Category: Weitzberg M]]
-[[Category: Weitzberg, M.]]
+[[Category: Wendt MD]]
-[[Category: Wendt, M D.]]
+[[Category: Zhao X]]
-[[Category: Zhao, X.]]
-[[Category: Egf-like domain]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Kringle]]
-[[Category: Plasminogen activation]]
-[[Category: Serine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:16:16 2008''