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[[Image:1npy.png|left|200px]]


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==Structure of shikimate 5-dehydrogenase-like protein HI0607==
The line below this paragraph, containing "STRUCTURE_1npy", creates the "Structure Box" on the page.
<StructureSection load='1npy' size='340' side='right'caption='[[1npy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1npy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPY FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
{{STRUCTURE_1npy|  PDB=1npy  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npy OCA], [https://pdbe.org/1npy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npy RCSB], [https://www.ebi.ac.uk/pdbsum/1npy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npy ProSAT], [https://www.topsan.org/Proteins/MCSG/1npy TOPSAN]</span></td></tr>
 
</table>
===Structure of shikimate 5-dehydrogenase-like protein HI0607===
== Function ==
 
[https://www.uniprot.org/uniprot/SHDHL_HAEIN SHDHL_HAEIN] In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.<ref>PMID:15735308</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npy_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1NPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPY OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npy ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae., Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D, J Biol Chem. 2005 Apr 29;280(17):17101-8. Epub 2005 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15735308 15735308]
<references/>
__TOC__
</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Collart, F.]]
[[Category: Collart F]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Korolev, S.]]
[[Category: Korolev S]]
[[Category: Koroleva, O.]]
[[Category: Koroleva O]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Zarembinski T]]
[[Category: Zarembinski, T.]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:13:15 2008''

Latest revision as of 10:58, 14 February 2024

Structure of shikimate 5-dehydrogenase-like protein HI0607Structure of shikimate 5-dehydrogenase-like protein HI0607

Structural highlights

1npy is a 4 chain structure with sequence from Haemophilus influenzae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.75Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

SHDHL_HAEIN In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. J Biol Chem. 2005 Apr 29;280(17):17101-8. Epub 2005 Feb 25. PMID:15735308 doi:10.1074/jbc.M412753200

1npy, resolution 1.75Å

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