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New page: left|200px<br /><applet load="1k4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k4r, resolution 24.Å" /> '''Structure of Dengue V... |
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== | ==Structure of Dengue Virus== | ||
The first structure of a flavivirus has been determined by using a | <SX load='1k4r' size='340' side='right' viewer='molstar' caption='[[1k4r]], [[Resolution|resolution]] 24.00Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1k4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chimeric_Tick-borne_encephalitis_virus/Dengue_virus_4 Chimeric Tick-borne encephalitis virus/Dengue virus 4]. The July 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 24Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4r OCA], [https://pdbe.org/1k4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4r RCSB], [https://www.ebi.ac.uk/pdbsum/1k4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/C3V005_9FLAV C3V005_9FLAV] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k4r_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k4r ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane. | |||
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.,Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH Cell. 2002 Mar 8;108(5):717-25. PMID:11893341<ref>PMID:11893341</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1k4r" style="background-color:#fffaf0;"></div> | |||
[[Category: Tick-borne encephalitis virus]] | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: | [[Category: Chimeric Tick-borne encephalitis virus/Dengue virus 4]] | ||
[[Category: | [[Category: Dengue Virus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: | [[Category: Baker TS]] | ||
[[Category: | [[Category: Chipman PR]] | ||
[[Category: Corver J]] | |||
[[Category: | [[Category: Jones CT]] | ||
[[Category: | [[Category: Kuhn RJ]] | ||
[[Category: | [[Category: Lenches E]] | ||
[[Category: | [[Category: Mukhopadhyay S]] | ||
[[Category: | [[Category: Pletnev SV]] | ||
[[Category: | [[Category: Rossmann MG]] | ||
[[Category: Strauss EG]] | |||
[[Category: Strauss JH]] | |||
[[Category: Zhang W]] | |||
Latest revision as of 09:52, 30 October 2024
Structure of Dengue VirusStructure of Dengue Virus
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