1k4e: Difference between revisions

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New page: left|200px<br /><applet load="1k4e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k4e, resolution 2.00Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1k4e.jpg|left|200px]]<br /><applet load="1k4e" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1k4e, resolution 2.00&Aring;" />
'''CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE'''<br />


==About this Structure==
==CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE==
1K4E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K4E OCA].  
<StructureSection load='1k4e' size='340' side='right'caption='[[1k4e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Beta-lactamase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1k4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K4E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k4e OCA], [https://pdbe.org/1k4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k4e RCSB], [https://www.ebi.ac.uk/pdbsum/1k4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k4e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLO10_PSEAI BLO10_PSEAI] Hydrolyzes both carbenicillin and oxacillin.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/1k4e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k4e ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Single protein]]
[[Category: Bouillene F]]
[[Category: Bouillene, F.]]
[[Category: Charlier P]]
[[Category: Charlier, P.]]
[[Category: Fonze E]]
[[Category: Fonze, E.]]
[[Category: Frere JM]]
[[Category: Frere, J.M.]]
[[Category: Kerff F]]
[[Category: Kerff, F.]]
[[Category: SO4]]
[[Category: beta-lactamase]]
[[Category: carbamylated lysine]]
[[Category: hydrolase]]
[[Category: mad phasing]]
[[Category: selenomethionine]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:50:53 2007''

Latest revision as of 12:42, 21 December 2022

CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINECRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE

Structural highlights

1k4e is a 2 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLO10_PSEAI Hydrolyzes both carbenicillin and oxacillin.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1k4e, resolution 2.00Å

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