2cxs: Difference between revisions

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{{Seed}}
[[Image:2cxs.png|left|200px]]


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==Crystal structure of mouse AMF / F6P complex==
The line below this paragraph, containing "STRUCTURE_2cxs", creates the "Structure Box" on the page.
<StructureSection load='2cxs' size='340' side='right'caption='[[2cxs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cxs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CXS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2cxs| PDB=2cxs |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cxs OCA], [https://pdbe.org/2cxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cxs RCSB], [https://www.ebi.ac.uk/pdbsum/2cxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cxs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G6PI_MOUSE G6PI_MOUSE] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/2cxs_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cxs ConSurf].
<div style="clear:both"></div>


===Crystal structure of mouse AMF / F6P complex===
==See Also==
 
*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
 
__TOC__
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_16375918}}
 
==About this Structure==
2CXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CXS OCA].
 
==Reference==
Crystal structures of mouse autocrine motility factor in complex with carbohydrate phosphate inhibitors provide insight into structure-activity relationship of the inhibitors., Tanaka N, Haga A, Naba N, Shiraiwa K, Kusakabe Y, Hashimoto K, Funasaka T, Nagase H, Raz A, Nakamura KT, J Mol Biol. 2006 Feb 17;356(2):312-24. Epub 2005 Dec 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16375918 16375918]
[[Category: Glucose-6-phosphate isomerase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Funasaka T]]
[[Category: Funasaka, T.]]
[[Category: Haga A]]
[[Category: Haga, A.]]
[[Category: Hashimoto K]]
[[Category: Hashimoto, K.]]
[[Category: Kusakabe Y]]
[[Category: Kusakabe, Y.]]
[[Category: Naba N]]
[[Category: Naba, N.]]
[[Category: Nagase H]]
[[Category: Nagase, H.]]
[[Category: Nakamura KT]]
[[Category: Nakamura, K T.]]
[[Category: Raz A]]
[[Category: Raz, A.]]
[[Category: Shiraiwa K]]
[[Category: Shiraiwa, K.]]
[[Category: Tanaka N]]
[[Category: Tanaka, N.]]
[[Category: Isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:58:01 2008''

Latest revision as of 16:44, 13 March 2024

Crystal structure of mouse AMF / F6P complexCrystal structure of mouse AMF / F6P complex

Structural highlights

2cxs is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G6PI_MOUSE Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cxs, resolution 1.50Å

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