3c72: Difference between revisions

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[[Image:3c72.jpg|left|200px]]


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==Engineered RabGGTase in complex with a peptidomimetic inhibitor==
The line below this paragraph, containing "STRUCTURE_3c72", creates the "Structure Box" on the page.
<StructureSection load='3c72' size='340' side='right'caption='[[3c72]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C72 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CX1:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-L-TYROSINE'>CX1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3c72| PDB=3c72 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c72 OCA], [https://pdbe.org/3c72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c72 RCSB], [https://www.ebi.ac.uk/pdbsum/3c72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c72 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c72_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c72 ConSurf].
<div style="clear:both"></div>


===Engineered RabGGTase in complex with a peptidomimetic inhibitor===
==See Also==
 
*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3C72 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA].
[[Category: Large Structures]]
 
==Reference==
Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex., Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H, Angew Chem Int Ed Engl. 2008;47(20):3747-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18399557 18399557]
[[Category: Protein complex]]
[[Category: Protein geranylgeranyltransferase type II]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Alexandrov, K.]]
[[Category: Alexandrov K]]
[[Category: Arndt, S.]]
[[Category: Arndt S]]
[[Category: Blankenfeldt, W.]]
[[Category: Blankenfeldt W]]
[[Category: Bon, R S.]]
[[Category: Bon RS]]
[[Category: Delon, C.]]
[[Category: Delon C]]
[[Category: Goody, R S.]]
[[Category: Goody RS]]
[[Category: Guiu-Rozas, E.]]
[[Category: Guiu-Rozas E]]
[[Category: Guo, Z.]]
[[Category: Guo Z]]
[[Category: Nguyen, U T.]]
[[Category: Nguyen UT]]
[[Category: Tan, K T.]]
[[Category: Tan KT]]
[[Category: Waldmann, H.]]
[[Category: Waldmann H]]
[[Category: Wetzel, S.]]
[[Category: Wetzel S]]
[[Category: Wu, Y W.]]
[[Category: Wu YW]]
[[Category: Metal-binding]]
[[Category: Peptide inhibitor]]
[[Category: Phosphoprotein]]
[[Category: Prenyltransferase]]
[[Category: Rab prenylation]]
[[Category: Transferase]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:46:54 2008''

Latest revision as of 15:23, 30 August 2023

Engineered RabGGTase in complex with a peptidomimetic inhibitorEngineered RabGGTase in complex with a peptidomimetic inhibitor

Structural highlights

3c72 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PGTA_RAT Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3c72, resolution 2.30Å

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OCA
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