2pgi: Difference between revisions

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[[Image:2pgi.png|left|200px]]


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==THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE-AN ENZYME WITH AUTOCRINE MOTILITY FACTOR ACTIVITY IN TUMOR CELLS==
The line below this paragraph, containing "STRUCTURE_2pgi", creates the "Structure Box" on the page.
<StructureSection load='2pgi' size='340' side='right'caption='[[2pgi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. The May 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Aconitase and Iron Regulatory Protein 1''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_5 10.2210/rcsb_pdb/mom_2007_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PGI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pgi OCA], [https://pdbe.org/2pgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pgi RCSB], [https://www.ebi.ac.uk/pdbsum/2pgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pgi ProSAT]</span></td></tr>
{{STRUCTURE_2pgi|  PDB=2pgi |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/G6PI2_GEOSE G6PI2_GEOSE] Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.[HAMAP-Rule:MF_00473]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pg/2pgi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pgi ConSurf].
<div style="clear:both"></div>


===THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE-AN ENZYME WITH AUTOCRINE MOTILITY FACTOR ACTIVITY IN TUMOR CELLS===
==See Also==
 
*[[Phosphoglucose isomerase 3D structures|Phosphoglucose isomerase 3D structures]]
 
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{{ABSTRACT_PUBMED_10318897}}
 
==About this Structure==
2PGI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Additional information on 2PGI is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PGI OCA].
 
==Reference==
The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin., Sun YJ, Chou CC, Chen WS, Wu RT, Meng M, Hsiao CD, Proc Natl Acad Sci U S A. 1999 May 11;96(10):5412-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10318897 10318897]
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Aconitase and Iron Regulatory Protein 1]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Glucose-6-phosphate isomerase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Chen, W S.]]
[[Category: Chen W-S]]
[[Category: Chou, C C.]]
[[Category: Chou C-C]]
[[Category: Hsiao, C D.]]
[[Category: Hsiao C-D]]
[[Category: Meng, M.]]
[[Category: Meng M]]
[[Category: Sun, Y J.]]
[[Category: Sun Y-J]]
[[Category: Autocrinefactor]]
[[Category: Crystallography]]
[[Category: Glycolysis]]
[[Category: Motility]]
[[Category: Neuroleukin]]
[[Category: Phosphoglucose isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:47:41 2008''

Latest revision as of 12:09, 21 February 2024

THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE-AN ENZYME WITH AUTOCRINE MOTILITY FACTOR ACTIVITY IN TUMOR CELLSTHE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE-AN ENZYME WITH AUTOCRINE MOTILITY FACTOR ACTIVITY IN TUMOR CELLS

Structural highlights

2pgi is a 1 chain structure with sequence from Geobacillus stearothermophilus. The May 2007 RCSB PDB Molecule of the Month feature on Aconitase and Iron Regulatory Protein 1 by David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G6PI2_GEOSE Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.[HAMAP-Rule:MF_00473]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2pgi, resolution 2.30Å

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