3bf1: Difference between revisions

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[[Image:3bf1.png|left|200px]]


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==Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate and ADP==
The line below this paragraph, containing "STRUCTURE_3bf1", creates the "Structure Box" on the page.
<StructureSection load='3bf1' size='340' side='right'caption='[[3bf1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bf1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BF1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BF1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene></td></tr>
{{STRUCTURE_3bf1| PDB=3bf1 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bf1 OCA], [https://pdbe.org/3bf1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bf1 RCSB], [https://www.ebi.ac.uk/pdbsum/3bf1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bf1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COAX_THEMA COAX_THEMA] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.<ref>PMID:16855243</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bf1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bf1 ConSurf].
<div style="clear:both"></div>


===Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate and ADP===
==See Also==
 
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 18186650 is the PubMed ID number.
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_18186650}}
 
==About this Structure==
3BF1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BF1 OCA].
 
==Reference==
Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase., Yang K, Strauss E, Huerta C, Zhang H, Biochemistry. 2008 Feb 5;47(5):1369-80. Epub 2008 Jan 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18186650 18186650]
[[Category: Pantothenate kinase]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Huerta, C.]]
[[Category: Huerta C]]
[[Category: Strauss, E.]]
[[Category: Strauss E]]
[[Category: Yang, K.]]
[[Category: Yang K]]
[[Category: Zhang, H.]]
[[Category: Zhang H]]
[[Category: Actin-like fold]]
[[Category: Atp-binding]]
[[Category: Coenzyme a biosynthesis]]
[[Category: Cytoplasm]]
[[Category: Kinase]]
[[Category: Metal-binding]]
[[Category: Nucleotide-binding]]
[[Category: Potassium]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 22:01:30 2008''

Latest revision as of 12:28, 21 February 2024

Type III pantothenate kinase from Thermotoga maritima complexed with pantothenate and ADPType III pantothenate kinase from Thermotoga maritima complexed with pantothenate and ADP

Structural highlights

3bf1 is a 6 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

COAX_THEMA Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Yang K, Eyobo Y, Brand LA, Martynowski D, Tomchick D, Strauss E, Zhang H. Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria. J Bacteriol. 2006 Aug;188(15):5532-40. PMID:16855243 doi:188/15/5532

3bf1, resolution 2.30Å

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