1lc4: Difference between revisions

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-{{Seed}}
-[[Image:1lc4.png|left|200px]]
-<!--
+==Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site==
-The line below this paragraph, containing "STRUCTURE_1lc4", creates the "Structure Box" on the page.
+<StructureSection load='1lc4' size='340' side='right'caption='[[1lc4]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1lc4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LC4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TOY:TOBRAMYCIN'>TOY</scene></td></tr>
-{{STRUCTURE_1lc4|  PDB=1lc4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lc4 OCA], [https://pdbe.org/1lc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lc4 RCSB], [https://www.ebi.ac.uk/pdbsum/1lc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lc4 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Aminoglycoside antibiotics target the decoding aminoacyl site (A site) on the 16S ribosomal RNA and induce miscoding during translation. Here, we present the crystal structure, at 2.54 A resolution, of an RNA oligonucleotide containing the A site sequence complexed to the 4,6-disubstituted 2-deoxystreptamine aminoglycoside tobramycin. The three aminosugar rings making up tobramycin interact with the deep-groove atoms directly or via water molecules and stabilize a fully bulged-out conformation of adenines A(1492) and A(1493). The comparison between this structure and the one previously solved in the presence of paromomycin confirms the importance of the functional groups on the common neamine part of these two antibiotics for binding to RNA. Furthermore, the analysis of the present structure provides a molecular explanation to some of the resistance mechanisms that have spread among bacteria and rendered aminoglycoside antibiotics inefficient.
-===Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site===
+Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site.,Vicens Q, Westhof E Chem Biol. 2002 Jun;9(6):747-55. PMID:12079787<ref>PMID:12079787</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12079787}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1lc4" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12079787 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12079787}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LC4 OCA].
+[[Category: Vicens Q]]
+[[Category: Westhof E]]
-==Reference==
-Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site., Vicens Q, Westhof E, Chem Biol. 2002 Jun;9(6):747-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12079787 12079787]
-[[Category: Vicens, Q.]]
-[[Category: Westhof, E.]]
-[[Category: Adenine bulge]]
-[[Category: Antibiotic-rna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 12:19:12 2008''