1hng: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1hng.jpg|left|200px]]<br /><applet load="1hng" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1hng, resolution 2.8&Aring;" />
-'''CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2'''<br />
-==Overview==
+==CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2==
-The crystal structure of a soluble form of the T lymphocyte antigen CD2, provides the first complete view of the extracellular region of a cell, adhesion molecule. The topology of the molecule, which comprises two, immunoglobulin-like domains, is the same as that of the first two domains, of CD4 but the relative domain orientation is altered by a fairly flexible, linker region. The putative ligand-binding beta-sheet forms a flat surface, towards the top of the molecule. Crystal contacts between these surfaces, suggest a plausible model for the adhesive interaction.
+<StructureSection load='1hng' size='340' side='right'caption='[[1hng]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1hng]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HNG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hng OCA], [https://pdbe.org/1hng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hng RCSB], [https://www.ebi.ac.uk/pdbsum/1hng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hng ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CD2_RAT CD2_RAT] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hng_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hng ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.
-==About this Structure==
+Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.,Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI Nature. 1992 Nov 19;360(6401):232-9. PMID:1279440<ref>PMID:1279440</ref>
-HNG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HNG OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2., Jones EY, Davis SJ, Williams AF, Harlos K, Stuart DI, Nature. 1992 Nov 19;360(6401):232-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1279440 1279440]
+</div>
-[[Category: Rattus norvegicus]]
+<div class="pdbe-citations 1hng" style="background-color:#fffaf0;"></div>
-[[Category: Single protein]]
-[[Category: Davis, S.J.]]
-[[Category: Harlos, K.]]
-[[Category: Jones, E.Y.]]
-[[Category: Stuart, D.I.]]
-[[Category: Williams, A.F.]]
-[[Category: t lymphocyte adhesion glycoprotein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:40:22 2007''
+==See Also==
+*[[CD2|CD2]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus rattus]]
+[[Category: Davis SJ]]
+[[Category: Harlos K]]
+[[Category: Jones EY]]
+[[Category: Stuart DI]]
+[[Category: Williams AF]]