1k32: Difference between revisions

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[[Image:1k32.png|left|200px]]


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==Crystal structure of the tricorn protease==
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<StructureSection load='1k32' size='340' side='right'caption='[[1k32]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1k32]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K32 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k32 OCA], [https://pdbe.org/1k32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k32 RCSB], [https://www.ebi.ac.uk/pdbsum/1k32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k32 ProSAT]</span></td></tr>
{{STRUCTURE_1k32|  PDB=1k32  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the tricorn protease===
[https://www.uniprot.org/uniprot/TRI_THEAC TRI_THEAC] Tricorn degrades oligopeptides (probably derived from the proteasome) and channels the products to F1, F2 and F3 proteases, which then catalyze the terminal degradation step, yielding free amino acids.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k32 ConSurf].
1K32 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K32 OCA].  
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__TOC__
==Reference==
</StructureSection>
Crystal structure of the tricorn protease reveals a protein disassembly line., Brandstetter H, Kim JS, Groll M, Huber R, Nature. 2001 Nov 22;414(6862):466-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11719810 11719810]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
[[Category: Brandstetter, H.]]
[[Category: Brandstetter H]]
[[Category: Groll, M.]]
[[Category: Groll M]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Kim, J S.]]
[[Category: Kim J-S]]
[[Category: Beta propeller]]
[[Category: Proteasome]]
[[Category: Protein degradation]]
[[Category: Serine protease]]
[[Category: Substrate gating]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 22:09:01 2008''

Latest revision as of 10:44, 7 February 2024

Crystal structure of the tricorn proteaseCrystal structure of the tricorn protease

Structural highlights

1k32 is a 6 chain structure with sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRI_THEAC Tricorn degrades oligopeptides (probably derived from the proteasome) and channels the products to F1, F2 and F3 proteases, which then catalyze the terminal degradation step, yielding free amino acids.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1k32, resolution 2.00Å

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