1i0e: Difference between revisions

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[[Image:1i0e.png|left|200px]]


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==CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE==
The line below this paragraph, containing "STRUCTURE_1i0e", creates the "Structure Box" on the page.
<StructureSection load='1i0e' size='340' side='right'caption='[[1i0e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1i0e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I0E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i0e OCA], [https://pdbe.org/1i0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i0e RCSB], [https://www.ebi.ac.uk/pdbsum/1i0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i0e ProSAT]</span></td></tr>
{{STRUCTURE_1i0e| PDB=1i0e |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/KCRM_HUMAN KCRM_HUMAN] Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/1i0e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i0e ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE===
==See Also==
 
*[[Creatine kinase 3D structures|Creatine kinase 3D structures]]
 
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</StructureSection>
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{{ABSTRACT_PUBMED_11517911}}
 
==About this Structure==
1I0E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I0E OCA].
 
==Reference==
Structure of human muscle creatine kinase., Shen YQ, Tang L, Zhou HM, Lin ZJ, Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1196-200. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11517911 11517911]
[[Category: Creatine kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lin, Z J.]]
[[Category: Lin Z-J]]
[[Category: Shen, Y Q.]]
[[Category: Shen Y-Q]]
[[Category: Tang, L.]]
[[Category: Tang L]]
[[Category: Zhou, H M.]]
[[Category: Zhou H-M]]
[[Category: Dimer]]
[[Category: Double helix]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:13:27 2008''

Latest revision as of 16:24, 13 March 2024

CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLECRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE

Structural highlights

1i0e is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCRM_HUMAN Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1i0e, resolution 3.50Å

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