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[[Image:1ht1.png|left|200px]]


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==Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU==
The line below this paragraph, containing "STRUCTURE_1ht1", creates the "Structure Box" on the page.
<StructureSection load='1ht1' size='340' side='right'caption='[[1ht1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ht1]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HT1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
{{STRUCTURE_1ht1| PDB=1ht1 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ht1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ht1 OCA], [https://pdbe.org/1ht1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ht1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ht1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ht1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ht/1ht1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ht1 ConSurf].
<div style="clear:both"></div>


===Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
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</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_11709174}}
[[Category: Chung CH]]
 
[[Category: Eom SH]]
==About this Structure==
[[Category: Franklin MC]]
1HT1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HT1 OCA].
[[Category: Kamtekar S]]
 
[[Category: Seong IS]]
==Reference==
[[Category: Song JJ]]
Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU., Wang J, Song JJ, Seong IS, Franklin MC, Kamtekar S, Eom SH, Chung CH, Structure. 2001 Nov;9(11):1107-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11709174 11709174]
[[Category: Wang J]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Chung, C H.]]
[[Category: Eom, S H.]]
[[Category: Franklin, M C.]]
[[Category: Kamtekar, S.]]
[[Category: Seong, I S.]]
[[Category: Song, J J.]]
[[Category: Wang, J.]]
[[Category: Hslvu]]
[[Category: Peptidase-atpase complex]]
 
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