1hdq: Difference between revisions

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{{Seed}}
[[Image:1hdq.png|left|200px]]


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==Crystal structure of bovine pancreatic carboxypeptidase A complexed with D-N-hydroxyaminocarbonyl phenylalanine at 2.3 A==
The line below this paragraph, containing "STRUCTURE_1hdq", creates the "Structure Box" on the page.
<StructureSection load='1hdq' size='340' side='right'caption='[[1hdq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hdq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HDQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INF:D-[(N-HYDROXYAMINO)CARBONYL]PHENYLALANINE'>INF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1hdq| PDB=1hdq |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hdq OCA], [https://pdbe.org/1hdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hdq RCSB], [https://www.ebi.ac.uk/pdbsum/1hdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hdq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/1hdq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hdq ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF BOVINE PANCREATIC CARBOXYPEPTIDASE A COMPLEXED WITH D-N-HYDROXYAMINOCARBONYL PHENYLALANINE AT 2.3 A===
==See Also==
 
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
 
__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 11937361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11937361}}
 
==About this Structure==
1HDQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDQ OCA].
 
==Reference==
Insight into the stereochemistry in the inhibition of carboxypeptidase A with N-(hydroxyaminocarbonyl)phenylalanine: binding modes of an enantiomeric pair of the inhibitor to carboxypeptidase A., Cho JH, Kim DH, Chung SJ, Ha NC, Oh BH, Yong Choi K, Bioorg Med Chem. 2002 Jun;10(6):2015-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937361 11937361]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Carboxypeptidase A]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Cho JH]]
[[Category: Cho, J H.]]
[[Category: Choi KY]]
[[Category: Choi, K Y.]]
[[Category: Chung SJ]]
[[Category: Chung, S J.]]
[[Category: Ha N-C]]
[[Category: Ha, N C.]]
[[Category: Kim DH]]
[[Category: Kim, D H.]]
[[Category: Oh B-H]]
[[Category: Oh, B H.]]
[[Category: Cpa]]
[[Category: Inhibitor]]
[[Category: Lbhb]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:02:46 2008''

Latest revision as of 14:30, 27 March 2024

Crystal structure of bovine pancreatic carboxypeptidase A complexed with D-N-hydroxyaminocarbonyl phenylalanine at 2.3 ACrystal structure of bovine pancreatic carboxypeptidase A complexed with D-N-hydroxyaminocarbonyl phenylalanine at 2.3 A

Structural highlights

1hdq is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CBPA1_BOVIN Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1hdq, resolution 2.30Å

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