1gws: Difference between revisions

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-{{Seed}}
-[[Image:1gws.png|left|200px]]
-<!--
+==hexadecaheme high molecular weight cytochrome Hmc from Desulfovibrio vulgaris Hildenborough==
-The line below this paragraph, containing "STRUCTURE_1gws", creates the "Structure Box" on the page.
+<StructureSection load='1gws' size='340' side='right'caption='[[1gws]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1gws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Desulfovibrio_vulgaris_str._Hildenborough Desulfovibrio vulgaris str. Hildenborough]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWS FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-{{STRUCTURE_1gws|  PDB=1gws  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gws OCA], [https://pdbe.org/1gws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gws RCSB], [https://www.ebi.ac.uk/pdbsum/1gws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gws ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMWC_NITV2 HMWC_NITV2] HMWC (high-molecular-weight cytochrome c), ORF2, ORF3, ORF4, ORF5 and ORF6 in the HMC operon form a transmembrane protein complex that allows electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes that catalyze reduction of sulfates.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gws_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gws ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Sulfate-reducing bacteria contain a variety of multi-heme c-type cytochromes. The cytochrome of highest molecular weight (Hmc) contains 16 heme groups and is part of a transmembrane complex involved in the sulfate respiration pathway. We present the 2.42 A resolution crystal structure of the Desulfovibrio vulgaris Hildenborough cytochrome Hmc and a structural model of the complex with its physiological electron transfer partner, cytochrome c(3), obtained by NMR restrained soft-docking calculations. The Hmc is composed of three domains, which exist independently in different sulfate-reducing species, namely cytochrome c(3), cytochrome c(7), and Hcc. The complex involves the last heme at the C-terminal region of the V-shaped Hmc and heme 4 of cytochrome c(3), and represents an example for specific cytochrome-cytochrome interaction.
-===HEXADECAHEME HIGH MOLECULAR WEIGHT CYTOCHROME HMC FROM DESULFOVIBRIO VULGARIS HILDENBOROUGH===
+The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3).,Czjzek M, ElAntak L, Zamboni V, Morelli X, Dolla A, Guerlesquin F, Bruschi M Structure. 2002 Dec;10(12):1677-86. PMID:12467575<ref>PMID:12467575</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1gws" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_12467575}}, adds the Publication Abstract to the page
+*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 12467575 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12467575}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Desulfovibrio vulgaris str. Hildenborough]]
-GWS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWS OCA].
+[[Category: Large Structures]]
+[[Category: Bruschi M]]
-==Reference==
+[[Category: Czjzek M]]
-The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3)., Czjzek M, ElAntak L, Zamboni V, Morelli X, Dolla A, Guerlesquin F, Bruschi M, Structure. 2002 Dec;10(12):1677-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12467575 12467575]
+[[Category: Haser R]]
-[[Category: Desulfovibrio vulgaris]]
-[[Category: Single protein]]
-[[Category: Bruschi, M.]]
-[[Category: Czjzek, M.]]
-[[Category: Haser, R.]]
-[[Category: Electron transport]]
-[[Category: Heme]]
-[[Category: Multiheme cytochrome]]
-[[Category: Periplasmic,repeat]]
-[[Category: Signal]]
-[[Category: Sulfate reducing bacteria]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 06:14:01 2008''