1fzr: Difference between revisions

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-{{Seed}}
-[[Image:1fzr.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF BACTERIOPHAGE T7 ENDONUCLEASE I==
-The line below this paragraph, containing "STRUCTURE_1fzr", creates the "Structure Box" on the page.
+<StructureSection load='1fzr' size='340' side='right'caption='[[1fzr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fzr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzr OCA], [https://pdbe.org/1fzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzr RCSB], [https://www.ebi.ac.uk/pdbsum/1fzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzr ProSAT]</span></td></tr>
-{{STRUCTURE_1fzr|  PDB=1fzr  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENDO_BPT7 ENDO_BPT7] Junction-resolving enzyme that selectively binds and cleaves four-way (Holliday) DNA junctions present after viral genomic replication. These intermediates are created during DNA repair, processing of stalled replication forks and homologous genetic recombination. Introduces two nicks on the two non-crossing strands, at 5' sides of the junction. Participates also together with gp6 in the degradation of host chromosome to provide nucleotides for phage DNA synthesis.<ref>PMID:12628932</ref> <ref>PMID:23207296</ref> <ref>PMID:3972821</ref> <ref>PMID:9236119</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzr ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF BACTERIOPHAGE T7 ENDONUCLEASE I===
+==See Also==
+*[[Endonuclease 3D structures|Endonuclease 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_11135673}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 11135673 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Escherichia phage T7]]
-{{ABSTRACT_PUBMED_11135673}}
+[[Category: Large Structures]]
+[[Category: Convery MA]]
-==About this Structure==
+[[Category: Declais AC]]
-FZR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZR OCA].
+[[Category: Hadden JM]]
+[[Category: Lilley DMJ]]
-==Reference==
+[[Category: Phillips SEV]]
-Crystal structure of the Holliday junction resolving enzyme T7 endonuclease I., Hadden JM, Convery MA, Declais AC, Lilley DM, Phillips SE, Nat Struct Biol. 2001 Jan;8(1):62-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11135673 11135673]
-[[Category: Enterobacteria phage t7]]
-[[Category: Single protein]]
-[[Category: Convery, M A.]]
-[[Category: Declais, A C.]]
-[[Category: Hadden, J M.]]
-[[Category: Lilley, D M.J.]]
-[[Category: Phillips, S E.V.]]
-[[Category: Composite active site]]
-[[Category: Domain swapped]]
-[[Category: Holliday junction resolvase]]
-[[Category: Homodimer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:10:57 2008''