1dt2: Difference between revisions

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-{{Seed}}
-[[Image:1dt2.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B==
-The line below this paragraph, containing "STRUCTURE_1dt2", creates the "Structure Box" on the page.
+<StructureSection load='1dt2' size='340' side='right'caption='[[1dt2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dt2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DT2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dt2 OCA], [https://pdbe.org/1dt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dt2 RCSB], [https://www.ebi.ac.uk/pdbsum/1dt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dt2 ProSAT]</span></td></tr>
-{{STRUCTURE_1dt2|  PDB=1dt2  |  SCENE=  }}
+</table>
+== Function ==
-===CRYSTAL STRUCTURE OF EXFOLIATIVE TOXIN B===
+[https://www.uniprot.org/uniprot/ETB_STAAU ETB_STAAU] Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).<ref>PMID:2117445</ref> <ref>PMID:2384148</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_10752623}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 10752623 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dt2_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_10752623}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dt2 ConSurf].
-DT2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DT2 OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-Structural similarities and differences in Staphylococcus aureus exfoliative toxins A and B as revealed by their crystal structures., Papageorgiou AC, Plano LR, Collins CM, Acharya KR, Protein Sci. 2000 Mar;9(3):610-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10752623 10752623]
+__TOC__
-[[Category: Single protein]]
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Staphylococcus aureus]]
-[[Category: Acharya, K R.]]
+[[Category: Acharya KR]]
-[[Category: Collins, C M.]]
+[[Category: Collins CM]]
-[[Category: Papageorgiou, A C.]]
+[[Category: Papageorgiou AC]]
-[[Category: Plano, L R.W.]]
+[[Category: Plano LRW]]
-[[Category: Epidermolysis]]
-[[Category: Serine protease]]
-[[Category: Superantigen]]
-[[Category: Toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:34:35 2008''