1dbq: Difference between revisions

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-{{Seed}}
-[[Image:1dbq.png|left|200px]]
-<!--
+==DNA-BINDING REGULATORY PROTEIN==
-The line below this paragraph, containing "STRUCTURE_1dbq", creates the "Structure Box" on the page.
+<StructureSection load='1dbq' size='340' side='right'caption='[[1dbq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1dbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DBQ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-{{STRUCTURE_1dbq|  PDB=1dbq  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dbq OCA], [https://pdbe.org/1dbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dbq RCSB], [https://www.ebi.ac.uk/pdbsum/1dbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dbq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PURR_ECOLI PURR_ECOLI] Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.<ref>PMID:2404765</ref> <ref>PMID:2211500</ref> <ref>PMID:1400170</ref> <ref>PMID:14741201</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/1dbq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dbq ConSurf].
+<div style="clear:both"></div>
-===DNA-BINDING REGULATORY PROTEIN===
+==See Also==
+*[[Purine repressor|Purine repressor]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_7553867}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 7553867 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_7553867}}
-==About this Structure==
-DBQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DBQ OCA].
-==Reference==
-Mechanism of corepressor-mediated specific DNA binding by the purine repressor., Schumacher MA, Choi KY, Lu F, Zalkin H, Brennan RG, Cell. 1995 Oct 6;83(1):147-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7553867 7553867]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Brennan, R G.]]
+[[Category: Brennan RG]]
-[[Category: Choi, K Y.]]
+[[Category: Choi KY]]
-[[Category: Lu, F.]]
+[[Category: Lu F]]
-[[Category: Schumacher, M A.]]
+[[Category: Schumacher MA]]
-[[Category: Zalkin, H.]]
+[[Category: Zalkin H]]
-[[Category: Dna-binding regulatory protein]]
-[[Category: Purine repressor]]
-[[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:47:17 2008''