1cic: Difference between revisions

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-{{Seed}}
-[[Image:1cic.png|left|200px]]
-<!--
+==IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225==
-The line below this paragraph, containing "STRUCTURE_1cic", creates the "Structure Box" on the page.
+<StructureSection load='1cic' size='340' side='right'caption='[[1cic]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CIC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cic OCA], [https://pdbe.org/1cic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cic RCSB], [https://www.ebi.ac.uk/pdbsum/1cic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cic ProSAT]</span></td></tr>
-{{STRUCTURE_1cic|  PDB=1cic  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/I6L958_MOUSE I6L958_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1cic_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cic ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Serologically detected antigenic determinants unique to an antibody or group of antibodies are called idiotopes. The sum of idiotopes of an antibody constitute its idiotype. Idiotypes have been intensively studied following a hypothesis for the self-regulation of the immune system through a network of idiotype-anti-idiotype interactions. Furthermore, as antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image' of the external antigen. Here we describe the structure of the complex between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic FabE225 at 2.5 A resolution. This complex defines a private idiotope consisting of 13 amino-acid residues, mainly from the complementarity-determining regions of D1.3. Seven of these residues make contacts with the antigen, indicating a significant overlap between idiotope and antigen-combining site. Idiotopic mimicry of the external antigen is not achieved at the molecular level in this example.
-===IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225===
+Three-dimensional structure of an idiotope-anti-idiotope complex.,Bentley GA, Boulot G, Riottot MM, Poljak RJ Nature. 1990 Nov 15;348(6298):254-7. PMID:1700305<ref>PMID:1700305</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_1700305}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1cic" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 1700305 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_1700305}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-CIC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA].
-==Reference==
-Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1700305 1700305]
 [[Category: Mus musculus]]
-[[Category: Protein complex]]
+[[Category: Bentley GA]]
-[[Category: Bentley, G A.]]
-[[Category: Anti-idiotope]]
-[[Category: Fab complex]]
-[[Category: Idiotope]]
-[[Category: Immunoglobulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:47:10 2008''