1anp: Difference between revisions

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-{{Seed}}
-[[Image:1anp.png|left|200px]]
-<!--
+==SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR==
-The line below this paragraph, containing "STRUCTURE_1anp", creates the "Structure Box" on the page.
+<StructureSection load='1anp' size='340' side='right'caption='[[1anp]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1anp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ANP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1anp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1anp OCA], [https://pdbe.org/1anp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1anp RCSB], [https://www.ebi.ac.uk/pdbsum/1anp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1anp ProSAT]</span></td></tr>
-{{STRUCTURE_1anp|  PDB=1anp  |  SCENE=  }}
+</table>
+== Disease ==
-===SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR===
+[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[https://omim.org/entry/612201 612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_8043577}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 8043577 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_8043577}}
-==About this Structure==
-ANP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ANP OCA].
-==Reference==
-Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor., Fairbrother WJ, McDowell RS, Cunningham BC, Biochemistry. 1994 Aug 2;33(30):8897-904. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8043577 8043577]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Cunningham, B C.]]
+[[Category: Cunningham BC]]
-[[Category: Fairbrother, W J.]]
+[[Category: Fairbrother WJ]]
-[[Category: Mcdowell, R S.]]
+[[Category: Mcdowell RS]]
-[[Category: Hypotensive hormone]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 17:13:38 2008''