2bs5: Difference between revisions

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OCA

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-[[Image:2bs5.gif|left|200px]]<br />
-<applet load="2bs5" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2bs5, resolution 2.10&Aring;" />
-'''LECTIN FROM RALSTONIA SOLANACEARUM COMPLEXED WITH 2-FUCOSYLLACTOSE'''<br />
-==Overview==
+==LECTIN FROM RALSTONIA SOLANACEARUM COMPLEXED WITH 2-FUCOSYLLACTOSE==
-Plant pathogens, like animal ones, use protein-carbohydrate interactions, in their strategy for host recognition, attachment, and invasion. The, bacterium Ralstonia solanacearum, which is distributed worldwide and, causes lethal wilt in many agricultural crops, was shown to produce a, potent L-fucose-binding lectin, R. solanacearum lectin, a small protein of, 90 amino acids with a tandem repeat in its amino acid sequence. In the, present study, surface plasmon resonance experiments conducted on a series, of oligosaccharides show a preference for binding to alphaFuc1-2Gal and, alphaFuc1-6Gal epitopes. Titration microcalorimetry demonstrates the, presence of two binding sites per monomer and an unusually high affinity, of the lectin for alphaFuc1-2Gal-containing oligosaccharides (KD = 2.5 ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15923179 (full description)]]
+<StructureSection load='2bs5' size='340' side='right'caption='[[2bs5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[2bs5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BS5 FirstGlance]. <br>
-BS5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ralstonia_solanacearum Ralstonia solanacearum]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BS5 OCA]].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900070:2-fucosyllactose'>PRD_900070</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bs5 OCA], [https://pdbe.org/2bs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bs5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bs5 ProSAT]</span></td></tr>
-The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan., Kostlanova N, Mitchell EP, Lortat-Jacob H, Oscarson S, Lahmann M, Gilboa-Garber N, Chambat G, Wimmerova M, Imberty A, J Biol Chem. 2005 Jul 29;280(30):27839-49. Epub 2005 May 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15923179 15923179]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0S4TLR1_RALSL A0A0S4TLR1_RALSL]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Ralstonia solanacearum]]
-[[Category: Single protein]]
+[[Category: Imberty A]]
-[[Category: Imberty, A.]]
+[[Category: Kostlanova N]]
-[[Category: Kostlanova, N.]]
+[[Category: Mitchell EP]]
-[[Category: Mitchell, E.P.]]
+[[Category: Wimmerova M]]
-[[Category: Wimmerova, M.]]
-[[Category: CL]]
-[[Category: beta-propeller]]
-[[Category: lectin]]
-[[Category: sugar recognition]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:35:45 2007''