1cdd: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1cdd.gif|left|200px]]<br /><applet load="1cdd" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1cdd, resolution 2.8&Aring;" />
-'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''<br />
-==Overview==
+==STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE==
-The three-dimensional structure of phosphoribosylglycinamide, formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide, formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at, 2.8-A resolution and as a ternary complex with the substrate glycinamide, ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure, is a modified doubly wound alpha/beta sheet with flexibility in the active, site, including a disordered loop in the apo structure, which is ordered, in the ternary complex structure. This enzyme is a target for anti-cancer, therapy and now for structure-based drug design.
+<StructureSection load='1cdd' size='340' side='right'caption='[[1cdd]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1cdd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CDD FirstGlance]. <br>
-CDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cdd OCA], [https://pdbe.org/1cdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cdd RCSB], [https://www.ebi.ac.uk/pdbsum/1cdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cdd ProSAT]</span></td></tr>
-Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1631098 1631098]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PUR3_ECOLI PUR3_ECOLI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/1cdd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cdd ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Phosphoribosylglycinamide formyltransferase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Almassy RJ]]
-[[Category: Almassy, R.J.]]
+[[Category: Hostomska Z]]
-[[Category: Hostomska, Z.]]
+[[Category: Janson CA]]
-[[Category: Janson, C.A.]]
+[[Category: Kan C-C]]
-[[Category: Kan, C.C.]]
-[[Category: PO4]]
-[[Category: transferase(formyl)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:21:54 2007''