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[[Image:2gjm.gif|left|200px]]


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==Crystal structure of Buffalo lactoperoxidase at 2.75A resolution==
The line below this paragraph, containing "STRUCTURE_2gjm", creates the "Structure Box" on the page.
<StructureSection load='2gjm' size='340' side='right'caption='[[2gjm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2gjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
{{STRUCTURE_2gjm| PDB=2gjm |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjm OCA], [https://pdbe.org/2gjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjm RCSB], [https://www.ebi.ac.uk/pdbsum/2gjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjm ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Buffalo lactoperoxidase at 2.75A resolution'''
==See Also==
 
*[[Lactoperoxidase|Lactoperoxidase]]
 
== References ==
==About this Structure==
<references/>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA].
__TOC__
[[Category: Peroxidase]]
</StructureSection>
[[Category: Ethayathulla, A S.]]
[[Category: Bubalus bubalis]]
[[Category: Sharma, S.]]
[[Category: Large Structures]]
[[Category: Sheikh, I A.]]
[[Category: Ethayathulla AS]]
[[Category: Singh, A K.]]
[[Category: Sharma S]]
[[Category: Singh, N.]]
[[Category: Sheikh IA]]
[[Category: Singh, T P.]]
[[Category: Singh AK]]
[[Category: Buffalo]]
[[Category: Singh N]]
[[Category: Crystal structure]]
[[Category: Singh TP]]
[[Category: Lactoperoxidase]]
[[Category: Oxidoreductase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun  5 10:02:46 2008''

Latest revision as of 11:04, 30 October 2024

Crystal structure of Buffalo lactoperoxidase at 2.75A resolutionCrystal structure of Buffalo lactoperoxidase at 2.75A resolution

Structural highlights

2gjm is a 1 chain structure with sequence from Bubalus bubalis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.75Å
Ligands:, , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_BUBBU Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Ozdemir H, Hacibeyoglu HI, Uslu H. Purification of lactoperoxidase from creek-water buffalo milk and investigation of kinetic and antibacterial properties. Prep Biochem Biotechnol. 2002 May;32(2):143-55. PMID:12071645 doi:http://dx.doi.org/10.1081/PB-120004127

2gjm, resolution 2.75Å

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