3bfx: Difference between revisions

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==Crystal structure of human sulfotransferase SULT1C1 in complex with PAP==
The line below this paragraph, containing "STRUCTURE_3bfx", creates the "Structure Box" on the page.
<StructureSection load='3bfx' size='340' side='right'caption='[[3bfx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2etg 2etg] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhe 1zhe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BFX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
{{STRUCTURE_3bfx| PDB=3bfx |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfx OCA], [https://pdbe.org/3bfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bfx RCSB], [https://www.ebi.ac.uk/pdbsum/3bfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bfx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ST1C2_HUMAN ST1C2_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bfx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bfx ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human sulfotransferase SULT1C1 in complex with PAP'''
==See Also==
 
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3BFX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhe 1zhe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFX OCA].
 
==Reference==
Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)., Dombrovski L, Dong A, Bochkarev A, Plotnikov AN, Proteins. 2006 Sep 1;64(4):1091-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16804942 16804942]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Dombrovski, L.]]
[[Category: Dombrovski L]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Plotnikov, A N.]]
[[Category: Plotnikov AN]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Alternative splicing]]
[[Category: Cytoplasm]]
[[Category: Pap]]
[[Category: Polymorphism]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Sulfotransferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:43:46 2008''

Latest revision as of 15:08, 30 August 2023

Crystal structure of human sulfotransferase SULT1C1 in complex with PAPCrystal structure of human sulfotransferase SULT1C1 in complex with PAP

Structural highlights

3bfx is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entries 2etg and 1zhe. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST1C2_HUMAN Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3bfx, resolution 1.80Å

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