1gg2: Difference between revisions

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OCA

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-[[Image:1gg2.gif|left|200px]]<br />
-<applet load="1gg2" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1gg2, resolution 2.4&Aring;" />
-'''G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND'''<br />
-==Overview==
+==G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND==
-The crystallographic structure of the G protein heterotrimer Gi alpha, 1(GDP)beta 1 gamma 2 (at 2.3 A) reveals two nonoverlapping regions of, contact between alpha and beta, an extended interface between beta and, nearly all of gamma, and limited interaction of alpha with gamma. The, major alpha/beta interface covers switch II of alpha, and GTP-induced, rearrangement of switch II causes subunit dissociation during signaling., Alterations in GDP binding in the heterotrimer (compared with alpha-GDP), explain stabilization of the inactive conformation of alpha by beta gamma., Repeated WD motifs in beta form a circularized sevenfold beta propeller., The conserved cores of these motifs are a scaffold for display of their, more variable linkers on the exterior face of each propeller blade.
+<StructureSection load='1gg2' size='340' side='right'caption='[[1gg2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1gg2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. The October 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''G Proteins''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_10 10.2210/rcsb_pdb/mom_2004_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GG2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg2 OCA], [https://pdbe.org/1gg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1gg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gg2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/1gg2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gg2 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-GG2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GDP as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1GG2 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GG2 OCA].
+*[[Transducin 3D structures|Transducin 3D structures]]
+== References ==
-==Reference==
+<references/>
-The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2., Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR, Cell. 1995 Dec 15;83(6):1047-58. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8521505 8521505]
+__TOC__
+</StructureSection>
 [[Category: Bos taurus]]
 [[Category: G Proteins]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
+[[Category: RCSB PDB Molecule of the Month]]
 [[Category: Rattus norvegicus]]
-[[Category: Sprang, S.R.]]
+[[Category: Sprang SR]]
-[[Category: Wall, M.A.]]
+[[Category: Wall MA]]
-[[Category: GDP]]
-[[Category: complex (gtp-binding/transducer)]]
-[[Category: g protein]]
-[[Category: gtpase]]
-[[Category: propeller]]
-[[Category: ras]]
-[[Category: signal transduction protein]]
-[[Category: wd40]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:00:49 2007''