2rf0: Difference between revisions

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New page: left|200px<br /> <applet load="2rf0" size="450" color="white" frame="true" align="right" spinBox="true" caption="2rf0, resolution 2.00Å" /> '''Crystal structure o...
 
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[[Image:2rf0.gif|left|200px]]<br />
<applet load="2rf0" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2rf0, resolution 2.00&Aring;" />
'''Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain'''<br />


==Disease==
==Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain==
Known disease associated with this structure: Leukemia, transient, of Down syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=159595 159595]]
<StructureSection load='2rf0' size='340' side='right'caption='[[2rf0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf0 OCA], [https://pdbe.org/2rf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M3K10_HUMAN M3K10_HUMAN] Activates the JUN N-terminal pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf0 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2RF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with EDO as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA].
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C.H.]]
[[Category: Berridge G]]
[[Category: Berridge, G.]]
[[Category: Edwards AM]]
[[Category: Delft, F.von.]]
[[Category: Elkins J]]
[[Category: Edwards, A.M.]]
[[Category: Eswaran J]]
[[Category: Elkins, J.]]
[[Category: Keates T]]
[[Category: Eswaran, J.]]
[[Category: Knapp S]]
[[Category: Keates, T.]]
[[Category: Pike ACW]]
[[Category: Knapp, S.]]
[[Category: Savitsky P]]
[[Category: Pike, A.C.W.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Savitsky, P.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt, J.]]
[[Category: EDO]]
[[Category: atp-binding]]
[[Category: map3k10]]
[[Category: mkn28]]
[[Category: mlk2]]
[[Category: nucleotide-binding]]
[[Category: phosphorylation]]
[[Category: serine/threonine-protein kinase]]
[[Category: sgc]]
[[Category: sh3 domain]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
[[Category: tkl kinase]]
[[Category: transferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:37:07 2007''

Latest revision as of 14:55, 30 August 2023

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domainCrystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Structural highlights

2rf0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

M3K10_HUMAN Activates the JUN N-terminal pathway (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rf0, resolution 2.00Å

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OCA
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