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| <!-- | | ==Crystal structure of the monomeric porin OmpG== |
| The line below this paragraph, containing "STRUCTURE_2f1c", creates the "Structure Box" on the page.
| | <StructureSection load='2f1c' size='340' side='right'caption='[[2f1c]], [[Resolution|resolution]] 2.30Å' scene=''> |
| You may change the PDB parameter (which sets the PDB file loaded into the applet)
| | == Structural highlights == |
| or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| | <table><tr><td colspan='2'>[[2f1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F1C FirstGlance]. <br> |
| or leave the SCENE parameter empty for the default display.
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| --> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr> |
| {{STRUCTURE_2f1c| PDB=2f1c | SCENE= }}
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1c OCA], [https://pdbe.org/2f1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f1c RCSB], [https://www.ebi.ac.uk/pdbsum/2f1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f1c ProSAT]</span></td></tr> |
| | </table> |
| | == Function == |
| | [https://www.uniprot.org/uniprot/OMPG_ECOLI OMPG_ECOLI] Forms channels functionally larger than those of classical porins.<ref>PMID:11758943</ref> May act as a regulator of the RCS-phosphorelay signal transduction pathway.<ref>PMID:11758943</ref> |
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| '''Crystal structure of the monomeric porin OmpG'''
| | ==See Also== |
| | | *[[Porin 3D structures|Porin 3D structures]] |
| | | == References == |
| ==Overview== | | <references/> |
| The outer membrane (OM) of Gram-negative bacteria contains a large number of channel proteins that mediate the uptake of ions and nutrients necessary for growth and functioning of the cell. An important group of OM channel proteins are the porins, which mediate the non-specific, diffusion-based passage of small (<600 Da) polar molecules. All porins of Gram-negative bacteria that have been crystallized to date form stable trimers, with each monomer composed of a 16-stranded beta-barrel with a relatively narrow central pore. In contrast, the OmpG porin is unique, as it appears to function as a monomer. We have determined the X-ray crystal structure of OmpG from Escherichia coli to a resolution of 2.3 A. The structure shows a 14-stranded beta-barrel with a relatively simple architecture. Due to the absence of loops that fold back into the channel, OmpG has a large ( approximately 13 A) central pore that is considerably wider than those of other E. coli porins, and very similar in size to that of the toxin alpha-hemolysin. The architecture of the channel, together with previous biochemical and other data, suggests that OmpG may form a non-specific channel for the transport of larger oligosaccharides. The structure of OmpG provides the starting point for engineering studies aiming to generate selective channels and for the development of biosensors.
| | __TOC__ |
| | | </StructureSection> |
| ==About this Structure==
| | [[Category: Escherichia coli K-12]] |
| 2F1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1C OCA].
| | [[Category: Large Structures]] |
| | | [[Category: Subbarao GV]] |
| ==Reference== | | [[Category: Van den Berg B]] |
| Crystal structure of the monomeric porin OmpG., Subbarao GV, van den Berg B, J Mol Biol. 2006 Jul 21;360(4):750-9. Epub 2006 Jun 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16797588 16797588]
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| [[Category: Escherichia coli]] | |
| [[Category: Single protein]] | |
| [[Category: Berg, B van den.]]
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| [[Category: Subbarao, G V.]] | |
| [[Category: Beta barrel]] | |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:43 2008''
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