2f5y: Difference between revisions

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New page: left|200px<br /> <applet load="2f5y" size="450" color="white" frame="true" align="right" spinBox="true" caption="2f5y, resolution 2.39Å" /> '''Crystal Structure o...
 
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[[Image:2f5y.gif|left|200px]]<br />
<applet load="2f5y" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2f5y, resolution 2.39&Aring;" />
'''Crystal Structure of the PDZ Domain from Human RGS-3'''<br />


==About this Structure==
==Crystal Structure of the PDZ Domain from Human RGS-3==
2F5Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA].  
<StructureSection load='2f5y' size='340' side='right'caption='[[2f5y]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [https://pdbe.org/2f5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [https://www.ebi.ac.uk/pdbsum/2f5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5y ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berridge, G.]]
[[Category: Berridge G]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Colebrook, S.]]
[[Category: Colebrook S]]
[[Category: Debreczeni, J.]]
[[Category: Debreczeni J]]
[[Category: Delft, F.von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Gorrec F]]
[[Category: Gorrec, F.]]
[[Category: Johansson C]]
[[Category: Johansson, C.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Savitsky P]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Smee C]]
[[Category: Savitsky, P.]]
[[Category: Sundstrom M]]
[[Category: Smee, C.]]
[[Category: Turnbull A]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Turnbull, A.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Yang X]]
[[Category: Weigel, J.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: SO4]]
[[Category: human]]
[[Category: pdz domain]]
[[Category: rgs-3]]
[[Category: sgc]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:59:57 2007''

Latest revision as of 08:12, 17 October 2024

Crystal Structure of the PDZ Domain from Human RGS-3Crystal Structure of the PDZ Domain from Human RGS-3

Structural highlights

2f5y is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.39Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RGS3_HUMAN Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.[1] [2] [3] [4]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Druey KM, Blumer KJ, Kang VH, Kehrl JH. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature. 1996 Feb 22;379(6567):742-6. PMID:8602223 doi:http://dx.doi.org/10.1038/379742a0
  2. ↑ Dulin NO, Sorokin A, Reed E, Elliott S, Kehrl JH, Dunn MJ. RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. Mol Cell Biol. 1999 Jan;19(1):714-23. PMID:9858594
  3. ↑ Dulin NO, Pratt P, Tiruppathi C, Niu J, Voyno-Yasenetskaya T, Dunn MJ. Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis. J Biol Chem. 2000 Jul 14;275(28):21317-23. PMID:10749886 doi:http://dx.doi.org/10.1074/jbc.M910079199
  4. ↑ Shi CS, Lee SB, Sinnarajah S, Dessauer CW, Rhee SG, Kehrl JH. Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation. J Biol Chem. 2001 Jun 29;276(26):24293-300. Epub 2001 Apr 9. PMID:11294858 doi:http://dx.doi.org/10.1074/jbc.M100089200

2f5y, resolution 2.39Å

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