2aas: Difference between revisions

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-[[Image:2aas.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2aas", creates the "Structure Box" on the page.
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-{{STRUCTURE_2aas|  PDB=2aas  |  SCENE=  }}
-'''HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF RIBONUCLEASE A IN SOLUTION BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY'''
+==HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF RIBONUCLEASE A IN SOLUTION BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY==
+<StructureSection load='2aas' size='340' side='right'caption='[[2aas]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2aas]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AAS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 32 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aas OCA], [https://pdbe.org/2aas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aas RCSB], [https://www.ebi.ac.uk/pdbsum/2aas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aas ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/2aas_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aas ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+High-resolution three-dimensional structures of bovine pancreatic ribonuclease A in aqueous solution have been determined by nuclear magnetic resonance (NMR) spectroscopy combined with restrained molecular dynamics calculations. The structures are based on: (1) 464 interproton distance constraints with accurate upper and lower limits, determined from build-up rates of nuclear Overhauser effects (NOE) by using the complete relaxation matrix; (2) 999 more approximate upper limits for interproton distances; and (3) 42 dihedral angle constraints (37 for phi and 5 for chi 1). A total of 16 structures were calculated, which show a root-mean-square (r.m.s.) deviation of 0.66 A for the backbone atoms and 1.68 A for all heavy-atoms. The converged structures are highly similar to those found in the crystal state. r.m.s. deviation of backbone atom positions in the crystal as compared to those in the average solution structure is 0.92 A. Observed differences are concentrated in loop regions and in the neighborhood of His119 and His48 side-chains. Dynamic aspects, such as H/D amide proton exchange and side-chain mobility have been examined.
-==Overview==
+High-resolution three-dimensional structure of ribonuclease A in solution by nuclear magnetic resonance spectroscopy.,Santoro J, Gonzalez C, Bruix M, Neira JL, Nieto JL, Herranz J, Rico M J Mol Biol. 1993 Feb 5;229(3):722-34. PMID:8381876<ref>PMID:8381876</ref>
-High-resolution three-dimensional structures of bovine pancreatic ribonuclease A in aqueous solution have been determined by nuclear magnetic resonance (NMR) spectroscopy combined with restrained molecular dynamics calculations. The structures are based on: (1) 464 interproton distance constraints with accurate upper and lower limits, determined from build-up rates of nuclear Overhauser effects (NOE) by using the complete relaxation matrix; (2) 999 more approximate upper limits for interproton distances; and (3) 42 dihedral angle constraints (37 for phi and 5 for chi 1). A total of 16 structures were calculated, which show a root-mean-square (r.m.s.) deviation of 0.66 A for the backbone atoms and 1.68 A for all heavy-atoms. The converged structures are highly similar to those found in the crystal state. r.m.s. deviation of backbone atom positions in the crystal as compared to those in the average solution structure is 0.92 A. Observed differences are concentrated in loop regions and in the neighborhood of His119 and His48 side-chains. Dynamic aspects, such as H/D amide proton exchange and side-chain mobility have been examined.
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-AAS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAS OCA].
+</div>
+<div class="pdbe-citations 2aas" style="background-color:#fffaf0;"></div>
-==Reference==
+==See Also==
-High-resolution three-dimensional structure of ribonuclease A in solution by nuclear magnetic resonance spectroscopy., Santoro J, Gonzalez C, Bruix M, Neira JL, Nieto JL, Herranz J, Rico M, J Mol Biol. 1993 Feb 5;229(3):722-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8381876 8381876]
+*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bos taurus]]
-[[Category: Pancreatic ribonuclease]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Bruix M]]
-[[Category: Bruix, M.]]
+[[Category: Gonzalez C]]
-[[Category: Gonzalez, C.]]
+[[Category: Herranz J]]
-[[Category: Herranz, J.]]
+[[Category: Neira JL]]
-[[Category: Neira, J L.]]
+[[Category: Nieto JL]]
-[[Category: Nieto, J L.]]
+[[Category: Rico M]]
-[[Category: Rico, M.]]
+[[Category: Santoro J]]
-[[Category: Santoro, J.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:49:32 2008''