2cii: Difference between revisions

==The crystal structure of H-2Db complexed with a partial peptide epitope suggests an MHC Class I assembly-intermediate==

== Publication Abstract from PubMed ==

In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilization, we have used short synthetic peptides derived from the Sendai virus nucleoprotein epitope (residues 324-332, 1FAPGNYPAL9) to promote its folding in vitro of H-2D(b). We found that H-2D(b) can be stabilized by the pentapeptide 5NYPAL9, which is equivalent to the C-terminal portion of the optimal nonapeptide and includes both the P5 and P9 anchor residues. We have crystallized the complex of the H-2D(b) molecule with the pentamer and determined the structure to show how a quasi-stable MHC class I molecule can be formed by occupancy of a single binding pocket in the peptide-binding groove.

The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate.,Glithero A, Tormo J, Doering K, Kojima M, Jones EY, Elliott T J Biol Chem. 2006 May 5;281(18):12699-704. Epub 2006 Feb 14. PMID:16478731<ref>PMID:16478731</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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==See Also==

*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]

*[[MHC 3D structures|MHC 3D structures]]

<references/>

</StructureSection>

[[Category: Doering K]]

[[Category: Elliott T]]

[[Category: Glithero A]]

[[Category: Jones EY]]

[[Category: Kojima M]]

[[Category: Tormo J]]