2ajp: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2ajp.gif|left|200px]]<br />
-<applet load="2ajp" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2ajp, resolution 2.500&Aring;" />
-'''Crystal structure of a human pyridoxal kinase'''<br />
-==Disease==
+==Crystal structure of a human pyridoxal kinase==
-Known diseases associated with this structure: Paroxysmal nonkinesigenic dyskinesia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=609023 609023]], Polycystic kidney and hepatic disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606702 606702]]
+<StructureSection load='2ajp' size='340' side='right'caption='[[2ajp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ajp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AJP FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ajp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajp OCA], [https://pdbe.org/2ajp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ajp RCSB], [https://www.ebi.ac.uk/pdbsum/2ajp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ajp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDXK_HUMAN PDXK_HUMAN] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/2ajp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ajp ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-AJP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, UNX and ANP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyridoxal_kinase Pyridoxal kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.35 2.7.1.35] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AJP OCA].
+*[[Pyridoxal kinase|Pyridoxal kinase]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Pyridoxal kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C.]]
+[[Category: Atanassova A]]
-[[Category: Atanassova, A.]]
+[[Category: Bochkarev A]]
-[[Category: Bochkarev, A.]]
+[[Category: Dimov S]]
-[[Category: Dimov, S.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Ismail S]]
-[[Category: Ismail, S.]]
+[[Category: Park H]]
-[[Category: Park, H.]]
+[[Category: Sundstrom M]]
-[[Category: SGC, Structural.Genomics.Consortium.]]
+[[Category: Tempel W]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Tempel, W.]]
-[[Category: Weigelt, J.]]
-[[Category: ANP]]
-[[Category: MG]]
-[[Category: UNX]]
-[[Category: pyridoxal kinase]]
-[[Category: sgc]]
-[[Category: structural genomics]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 20:51:55 2007''