1vj6: Difference between revisions

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-[[Image:1vj6.jpg|left|200px]]
-<!--
+==PDZ2 from PTP-BL in complex with the C-terminal ligand from the APC protein==
-The line below this paragraph, containing "STRUCTURE_1vj6", creates the "Structure Box" on the page.
+<StructureSection load='1vj6' size='340' side='right'caption='[[1vj6]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1vj6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VJ6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj6 OCA], [https://pdbe.org/1vj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vj6 RCSB], [https://www.ebi.ac.uk/pdbsum/1vj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj6 ProSAT]</span></td></tr>
-{{STRUCTURE_1vj6|  PDB=1vj6  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN13_MOUSE PTN13_MOUSE] Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/1vj6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vj6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Understanding the basis of communication within protein domains is a major challenge in structural biology. We present structural and dynamical evidence for allosteric effects in a PDZ domain, PDZ2 from the tyrosine phosphatase PTP-BL, upon binding to a target peptide. The NMR structures of its free and peptide-bound states differ in the orientation of helix alpha2 with respect to the remainder of the molecule, concomitant with a readjustment of the hydrophobic core. Using an ultrafast mixing instrument, we detected a deviation from simple bimolecular kinetics for the association with peptide that is consistent with a rate-limiting conformational change in the protein (k(obs) approximately 7 x 10(3) s(-1)) and an induced-fit model. Furthermore, the binding kinetics of 15 mutants revealed that binding is regulated by long-range interactions, which can be correlated with the structural rearrangements resulting from peptide binding. The homologous protein PSD-95 PDZ3 did not display a similar ligand-induced conformational change.
-'''PDZ2 from PTP-BL in complex with the C-terminal ligand from the APC protein'''
+Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering.,Gianni S, Walma T, Arcovito A, Calosci N, Bellelli A, Engstrom A, Travaglini-Allocatelli C, Brunori M, Jemth P, Vuister GW Structure. 2006 Dec;14(12):1801-9. PMID:17161370<ref>PMID:17161370</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1vj6" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-VJ6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ6 OCA].
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Protein complex]]
+[[Category: Vuister GW]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Walma T]]
-[[Category: Vuister, G W.]]
-[[Category: Walma, T.]]
-[[Category: Apc]]
-[[Category: C-terminus]]
-[[Category: Complex]]
-[[Category: Nmr]]
-[[Category: Pdz]]
-[[Category: Protein-protein interaction]]
-[[Category: Ptp-bl]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:35:23 2008''