1uzc: Difference between revisions

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-[[Image:1uzc.gif|left|200px]]
-<!--
+==THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11==
-The line below this paragraph, containing "STRUCTURE_1uzc", creates the "Structure Box" on the page.
+<StructureSection load='1uzc' size='340' side='right'caption='[[1uzc]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1uzc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1h40 1h40]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UZC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uzc OCA], [https://pdbe.org/1uzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uzc RCSB], [https://www.ebi.ac.uk/pdbsum/1uzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uzc ProSAT]</span></td></tr>
-{{STRUCTURE_1uzc|  PDB=1uzc  |  SCENE=  }}
+</table>
+== Function ==
-'''THE STRUCTURE OF AN FF DOMAIN FROM HUMAN HYPA/FBP11'''
+[https://www.uniprot.org/uniprot/PR40A_HUMAN PR40A_HUMAN] Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.<ref>PMID:21834987</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==Overview==
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/1uzc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uzc ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The FF domain is a 60 amino acid residue phosphopeptide-binding module found in a variety of eukaryotic proteins including the transcription elongation factor CA150, the splicing factor Prp40 and p190RHOGAP. We have determined the structure of an FF domain from HYPA/FBP11. The domain is composed of three alpha helices arranged in an orthogonal bundle with a 3(10) helix in the loop between the second and third alpha helices. The structure differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold.
-==About this Structure==
+The structure of an FF domain from human HYPA/FBP11.,Allen M, Friedler A, Schon O, Bycroft M J Mol Biol. 2002 Oct 25;323(3):411-6. PMID:12381297<ref>PMID:12381297</ref>
-UZC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1h40 1h40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UZC OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-The structure of an FF domain from human HYPA/FBP11., Allen M, Friedler A, Schon O, Bycroft M, J Mol Biol. 2002 Oct 25;323(3):411-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12381297 12381297]
+</div>
+<div class="pdbe-citations 1uzc" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Allen, M D.]]
+[[Category: Allen MD]]
-[[Category: Bycroft, M.]]
+[[Category: Bycroft M]]
-[[Category: Friedler, A.]]
+[[Category: Friedler A]]
-[[Category: Jemth, P.]]
+[[Category: Jemth P]]
-[[Category: Schon, O.]]
+[[Category: Schon O]]
-[[Category: Nmr structure]]
-[[Category: Nuclear protein]]
-[[Category: Phosphopeptide recognition]]
-[[Category: Rna polymerase ii carboxyl-terminal domain]]
-[[Category: Transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:53:52 2008''