1uf8: Difference between revisions

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[[Image:1uf8.gif|left|200px]]


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==Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-Phenylalanine==
The line below this paragraph, containing "STRUCTURE_1uf8", creates the "Structure Box" on the page.
<StructureSection load='1uf8' size='340' side='right'caption='[[1uf8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1uf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UF8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ING:D-[(AMINO)CARBONYL]PHENYLALANINE'>ING</scene></td></tr>
{{STRUCTURE_1uf8|  PDB=1uf8  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf8 OCA], [https://pdbe.org/1uf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1uf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uf8 ProSAT]</span></td></tr>
 
</table>
'''Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-Phenylalanine'''
== Function ==
 
[https://www.uniprot.org/uniprot/DCAS_AGRSK DCAS_AGRSK] The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1UF8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF8 OCA].  
Check<jmol>
[[Category: Agrobacterium sp.]]
  <jmolCheckbox>
[[Category: N-carbamoyl-D-amino acid hydrolase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1uf8_consurf.spt"</scriptWhenChecked>
[[Category: Single protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Aoki, M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Hashimoto, H.]]
  </jmolCheckbox>
[[Category: Ikenaka, Y.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uf8 ConSurf].
[[Category: Morikawa, H.]]
<div style="clear:both"></div>
[[Category: Nakai, T.]]
__TOC__
[[Category: Sato, M.]]
</StructureSection>
[[Category: Shimizu, T.]]
[[Category: Agrobacterium sp]]
[[Category: Takahashi, S.]]
[[Category: Large Structures]]
[[Category: D-amino acid]]
[[Category: Aoki M]]
[[Category: Hydrolase]]
[[Category: Hashimoto H]]
[[Category: N-carbamyl-d-amino acid amidohydrolase]]
[[Category: Ikenaka Y]]
[[Category: N-carbamyl-d-phenylalanine]]
[[Category: Morikawa H]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:08:28 2008''
[[Category: Nakai T]]
[[Category: Sato M]]
[[Category: Shimizu T]]
[[Category: Takahashi S]]

Latest revision as of 02:52, 28 December 2023

Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-PhenylalanineCrystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-Phenylalanine

Structural highlights

1uf8 is a 2 chain structure with sequence from Agrobacterium sp.. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCAS_AGRSK The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1uf8, resolution 1.80Å

Drag the structure with the mouse to rotate

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OCA
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